The clearance of radioiron from plasma and its appearance in circulating erythrocytes in normal subjects are studied. The importance of correcting for plasma iron fluctuations and for mean body hematocrit is illustrated. The data are analyzed by probability theory to determine relationships between intravascular and extravascular iron. Two refluxes are described, one of about 7 particles of every 100 leaving the plasma, and the second of about 23. The return times of these are about 5 hours and 8 days, respectively.

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Blood Ferrokinetics in Normal Man

https://www.amjmed.com/article/0002-9343(70)90109-9/pdf

Hematologic and biochemical studies in a case of lead poisoning.

Bilirubin production as a measure of red cell life span

Transdermal Delivery of Iron Using Soluble Microneedles: Dermal Kinetics and Safety.

A useful stochastic model of iron kinetics is examined in terms of a mathematically equivalent multicompartment model. Although this model oversimplifies the process by which iron moves from the plasma to circulating red blood cells, it accurately describes iron kinetics under a variety of circumstances. Parameters of this compartment model are shown to be uniquely identifiable. A D -optimal ferrokinetic blood-sampling schedule based on the model achieves a 33% increase in efficiency over a schedule commonly used.

M H Witte

Papers

Studies in iron kinetics. i. interpretation of ferrokinetic data in man.