Cancer is the most deadly disease that causes the serious health problems, physical disabilities, mortalities, and morbidities around the world. It is the second leading cause of death all over the world. Although great advancement have been made in the treatment of cancer progression, still significant deficiencies and room for improvement remain. Chemotherapy produced a number of undesired and toxic side effects. Natural therapies, such as the use of plant-derived products in the treatment of cancer, may reduce adverse and toxic side effects. However, many plants exist that have shown very promising anticancer activities in vitro and in vivo but their active anticancer principle have yet to be evaluated. Combined efforts of botanist, pharmacologist and chemists are required to find new lead anticancer constituent to fight disease. This review will help researchers in the finding of new bioactive molecules as it will focus on various plants evaluated for anticancer properties in vitro and in vivo.

http://koreascience.or.kr:80/article/JAKO201426636276011.pdf

Medicinal plants combating against cancer--a green anticancer approach.

The extent of growth L. plantarum (LP), L. delbrueckii subsp. bulgaricus (LD), L. fermentum (LF), S. thermophilus (ST), B. longum (BI) and S. cerevisiae (SA) was generally good with the lower concentration of the ginseng extract. Total sapogenin content was slightly different with kinds of a fermentation microorganism and the time of fermentation process, and generally reduced compare to before fermentation. The content of ginsenoside Rb1, Rb2, Rb3, Re and Rf were decreased with the fermentation but ginsenoside Rd was increased by the E, LF and SA fermented extract. The content of compound K increased in the order of not-fermented extrac mg/10 g which was lower than it of a not-fermented extract ( mg/10 g). Flavonoid content of a ginseng fermented extract indicated mg/10 g, it was higher than a not-fermented extract ( mg/10 g). As the fermented time get longer, the flavonoid content tendency to increase. DPPH radical scavenging activity of a fermented ginseng extract was , it was slightly lower compared to a natural antioxidant, vitamin C. But it of the LF and ST fermented extract was similar to a natural antioxidant, vitamin C. It has not a concerned in a fermentation. Nitrite scavenging ability of a 24 hr fermented extract was above 80% at pH 2.5 and 4.2, it was similar to an artificial antioxidant, BHT (; pH2.5, ; pH 4.2). It has not a concerned in a fermentation. SOD-like activity of a fermented extract was lower than that of a not-fermented extract (), but it of the E and LP-fermented extract was a very highly notable value. As the fermented time get longer, the SOD-like activity tendency to increase.

https://www.koreascience.or.kr:443/article/JAKO201027742024067.pdf

Ginsenoside Change and Antioxidation Activity of Fermented Ginseng

 - % #   ( , -% +# *+' . /01$ %& $     '  #( )*   +    *  & & &  & & $  * && & +  &     * $"&& & &  , *     -*  & ,  *  &&  .  /     *  &$ *  & &  ,&  ,'  # α & $*& & &  ,!0%%$& $    0+120/0"3 & ,  &* & &&    -& * &&$* 24"456"6750+120/0"3 &  "68μ9   !$   ,'  #*   & $  &    *:* ' %%" &. %  ) 2   - ++% %  α/'( % % 344% %+

Nutritional Properties and Biological Activities of Artemisia annua L.

섬애약쑥, 인진쑥, 약쑥, 강화사자발쑥 및 개똥쑥 열수 추출물을 제조한 다음 항산화 및 항암활성을 비교 분석하였다. 5종의 쑥 추출물 중 총 페놀 함량은 인진쑥에서 유의적으로 가장 높았으며, 다음으로 섬애약쑥, 개똥쑥, 약쑥 및 강화사자발쑥 순이었다. 플라보노이드 함량도 인진쑥이 가장 높았고, 섬애약쑥은 인진쑥...

https://www.koreascience.or.kr:443/article/JAKO201222740953329.pdf

국내산 품종별 쑥의 항산화 및 암세포성장 억제활성

This study was conducted to investigate the antioxidative activity and cytotoxicity of fermented Allium victorialis extract The results were as follows; The total polyphenol content of A victorialis extract was 263 mg/g, and that of fermented A victorialis extract was 165 mg/g which decreased a little by fermentation The total flavonoid content of A victorialis extract was 5777 mg/g, and that of fermented A victorialis extract was 6227 mg/g, and this could increase a little from fermentation Electron donating ability of A victorialis extract was lower than vitamin C(9771%), but before fermentation it was 8229% and after fermentation it became 8240% Nitrite scavenging ability of A victorialis extract before and after fermentation showed lower numerical value than that of butylated hydroxytoluene(BHT) at pH 25 but that of A victorialis extract expressed higher than that of BHT Superoxide dismutase-like activity showed relatively low level, 15% Nitrite production increased by A victorialis extract but was inhibited after fermentation Methyl diamphetamine (MDA) content was inhibited with increased concentration of A victorialis extract compared with treatment but there was not any difference before and after fermentation Therefore, production of lipid peroxide(LPO) was inhibited by A victorialis extract Cell viability of fibroblast cell was tend to slightly decrease with increased concentration of A victorialis extract, but not different with control

/pdf/antioxidative-activity-and-cytotoxicity-of-fermented-allium-35j0955ium.pdf

Antioxidative Activity and Cytotoxicity of Fermented Allium victorialis L. Extract

− Artemisia capillaries is a major important food and medicinal resource in Korea. In order to confirm the biological activities of Artemisia capillaries, we investigated antioxidant and anticancer activities from in vitro assays. The Artemisia capillaries methanol (MeOH) extracts was used for the evaluation of DPPH scavenging, total phenolic content, total flavonoid content, hydroxyl radical (•OH) scavenging, reducing power assay as antioxidant activity, as well as anticancer activities as MTT assay. As a result, the Artemisia capillaries MeOH extracts showed potent antioxidative activity and anticancer activity in vitro. These results suggest that the Artemisia capillaries MeOH extracts have a potential alleviated oxidation process, cell motility activity, and tumorigenesis.

M.J. Jung

Papers

Antioxidant and Anticancer Activities of Extract from Artemisia capillaries