M
M L De Bruin
Researcher at Utrecht University
Publications - 25
Citations - 984
M L De Bruin is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Cancer. The author has an hindex of 14, co-authored 25 publications receiving 849 citations. Previous affiliations of M L De Bruin include University of Copenhagen.
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Journal ArticleDOI
Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death.
TL;DR: Findings are in support of the value of pre-clinical HERG testing to predict pro-arrhythmic effects of medicines.
Journal ArticleDOI
Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications
Victoria Abbing-Karahagopian,Consuelo Huerta,Patrick C. Souverein,F.J. de Abajo,Hubert G. M. Leufkens,Jim Slattery,Yolanda Alvarez,Montserrat Miret,Miguel Gil,Belén Oliva,Ulrik Hesse,Gema Requena,F. de Vries,F. de Vries,Marietta Rottenkolber,Sven Schmiedl,Robert F. Reynolds,Raymond G. Schlienger,M. C. H. de Groot,Olaf H. Klungel,T. P. van Staa,L. van Dijk,Antoine C. G. Egberts,Helga Gardarsdottir,M L De Bruin +24 more
TL;DR: Variations in the prevalence of antidepressant prescribing were obvious in the different populations despite applying uniform methods, and database characteristics and clinical factors may both explain these variations.
Journal ArticleDOI
Glucose-lowering agents and the patterns of risk for cancer: a study with the General Practice Research Database and secondary care data.
T. P. van Staa,T. P. van Staa,Deven Patel,Arlene M. Gallagher,Arlene M. Gallagher,M L De Bruin +5 more
TL;DR: These findings do not provide evidence of either beneficial or adverse effects of glucose-lowering agents on cancer risk and are consistent with changes in diabetes treatment in the few months prior to the diagnosis of cancer.
Journal ArticleDOI
Hospital discharge diagnoses of ventricular arrhythmias and cardiac arrest were useful for epidemiologic research.
TL;DR: Hospitalizations for ventricular cardiac arrhythmias and cardiac arrest have a high PPV and are useful for selecting events in epidemiological studies on drug-induced arrh rhythmias.
Journal ArticleDOI
Use of the conditional marketing authorization pathway for oncology medicines in Europe
TL;DR: Results indicate that CMA is not used by companies as a prospectively planned pathway to obtain early access, but as a “rescue option” when submitted data are not strong enough to justify full marketing authorization.