Toxicity is one of the major attrition causes during the drug development process. In that line, cardio-, neuro-, and hepatotoxicities are among the main reasons behind the retirement of drugs in clinical phases and post market withdrawal. Zebrafish exploitation in high-throughput drug screening is becoming an important tool to assess the toxicity and efficacy of novel drugs. This animal model has, from early developmental stages, fully functional organs from a physiological point of view. Thus, drug-induced organ-toxicity can be detected in larval stages, allowing a high predictive power on possible human drug-induced liabilities. Hence, zebrafish can bridge the gap between preclinical in vitro safety assays and rodent models in a fast and cost-effective manner. ZeGlobalTox is an innovative assay that sequentially integrates in vivo cardio-, neuro-, and hepatotoxicity assessment in the same animal, thus impacting strongly in the 3Rs principles. It Reduces, by up to a third, the number of animals required to assess toxicity in those organs. It Refines the drug toxicity evaluation through novel physiological parameters. Finally, it might allow the Replacement of classical species, such as rodents and larger mammals, thanks to its high predictivity (Specificity: 89%, Sensitivity: 68% and Accuracy: 78%).

/pdf/zeglobaltox-an-innovative-approach-to-address-organ-drug-4hvtp1kdyh.pdf

ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish

https://revistafarmaciahospitalaria.sefh.es/gdcr/index.php/fh/article/download/318/318

Revisión sobre el uso de medicamentos en condiciones no incluidas en su ficha técnica

Acute Hepatitis Associated with Treatment of Peyronie's Disease with Potassium Para‐Aminobenzoate (Potaba)

http://www.aulamedica.es/fh/pdf/ING/318.pdf

Review of use of drugs for conditions not included in product characteristics.

Frecuencia y características de las cartas al director publicadas en Farmacia Hospitalaria (1995-2006)

http://revistafarmaciahospitalaria.sefh.es/gdcr/index.php/fh/article/download/956/956

Hepatitis por finasterida

Esofagitis medicamentosa: disfagia de etiología poco frecuente

https://revistafarmaciahospitalaria.sefh.es/gdcr/index.php/fh/article/download/634/634

M. Martínez de Guzmán

Papers

Hepatitis por finasterida

Esofagitis medicamentosa: disfagia de etiología poco frecuente

Neurotoxicidad asociada a sales de litio