M
M. Spraul
Researcher at National Institutes of Health
Publications - 11
Citations - 2858
M. Spraul is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Basal metabolic rate & Insulin. The author has an hindex of 11, co-authored 11 publications receiving 2773 citations.
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Journal ArticleDOI
Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians
Stephen Lillioja,David M. Mott,M. Spraul,R T Ferraro,James E. Foley,Eric Ravussin,William C. Knowler,Peter H. Bennett,Clifton Bogardus +8 more
TL;DR: Obesity, insulin resistance, and low acute plasma insulin response to intravenous glucose (with the degree of obesity and insulin resistance taken into account) were predictors of NIDDM.
A Potential Mechanism Predisposing to Body Weight Gain
TL;DR: In this paper, the authors measured fasting muscle sympathetic nerve activity (MSNA) in the peroneal nerve and its relationship with energy expenditure and body composition in 25 relatively lean Pima Indian males (means±SD; 26±6 yr, 82±19 kg, 28±10% body fat) and 19 Caucasian males (29±5 yr, 81±13 kg, 24±9 % body fat).
Journal ArticleDOI
Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain.
TL;DR: The activity of the sympathetic nervous system is a determinant of energy expenditure in Caucasians and individuals with low resting MSNA may be at risk for body weight gain resulting from a lower metabolic rate.
Journal ArticleDOI
Determinants of total daily energy expenditure: variability in physical activity.
TL;DR: The results suggest that obesity is associated with lower levels of physical activity, and fat-free mass was the best single determinant of TEE, explaining 48% of its variance.
Journal ArticleDOI
Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians
Michal Prochazka,Stephen Lillioja,Jonathan F. Tait,William C. Knowler,David M. Mott,M. Spraul,Peter H. Bennett,Clifton Bogardus +7 more
TL;DR: Findings indicate that a gene on 4q, near the FABP2 and ANX5 loci, contributes to in vivo insulin action in Pima Indians.