C
Clifton Bogardus
Researcher at National Institutes of Health
Publications - 205
Citations - 23432
Clifton Bogardus is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Insulin & Type 2 diabetes. The author has an hindex of 62, co-authored 200 publications receiving 22237 citations. Previous affiliations of Clifton Bogardus include Indiana University & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus.
TL;DR: Defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes, and intervention to prevent diabetes should target both abnormalities.
Journal ArticleDOI
Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians
Stephen Lillioja,David M. Mott,M. Spraul,R T Ferraro,James E. Foley,Eric Ravussin,William C. Knowler,Peter H. Bennett,Clifton Bogardus +8 more
TL;DR: Obesity, insulin resistance, and low acute plasma insulin response to intravenous glucose (with the degree of obesity and insulin resistance taken into account) were predictors of NIDDM.
Journal ArticleDOI
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Yukio Horikawa,Naohisa Oda,Nancy J. Cox,Xiuping Li,Xiuping Li,Marju Orho-Melander,Manami Hara,Yoshinori Hinokio,Yoshinori Hinokio,Tom H. Lindner,Hirosato Mashima,Peter Eh Schwarz,Peter Eh Schwarz,L. del Bosque-Plata,L. del Bosque-Plata,Y. Oda,Issei Yoshiuchi,Susan Colilla,Kenneth S. Polonsky,S Wei,Patrick Concannon,Naoko Iwasaki,Jan Schulze,Leslie J. Baier,Clifton Bogardus,Leif Groop,Eric Boerwinkle,Craig L. Hanis,Graeme I. Bell +28 more
TL;DR: The positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland is described, suggesting a novel pathway that may contribute to the development of type 1 diabetes.
Journal ArticleDOI
Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain
Eric Ravussin,Stephen Lillioja,William C. Knowler,L. Christin,Daniel Freymond,William G H Abbott,Vicky L Boyce,Barbara V. Howard,Clifton Bogardus +8 more
TL;DR: It is concluded that a low rate of energy expenditure may contribute to the aggregation of obesity in families.
Journal ArticleDOI
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans
Reiner Jumpertz,Duc Son N.T. Le,Peter J. Turnbaugh,Cathy Trinidad,Clifton Bogardus,Jeffrey I. Gordon,Jonathan Krakoff +6 more
TL;DR: Results show that the nutrient load is a key variable that can influence the gut (fecal) bacterial community structure over short time scales and indicate a possible role of the human gut microbiota in the regulation of the nutrient harvest.