Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system

Apparent antioxidant effect of l-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo

The molecular pharmacology of L-deprenyl.

MAO-B inhibitors: multiple roles in the therapy of neurodegenerative disorders?

L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats.

(−)-Deprenyl (0.25 or 2mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate Superoxide dismutase activity measured. (−)-Deprenyl at 2mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (−)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed.

M. Walker

Papers

Deprenyl can induce soluble superoxide dismutase in rat striata.