M
M. Zuk
Researcher at Gdańsk Medical University
Publications - 4
Citations - 122
M. Zuk is an academic researcher from Gdańsk Medical University. The author has contributed to research in topics: Familial hypercholesterolemia & Mutation. The author has an hindex of 3, co-authored 4 publications receiving 105 citations.
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Journal ArticleDOI
Molecular characterization of Polish patients with familial hypercholesterolemia: novel and recurrent LDLR mutations.
M. Chmara,Bartosz Wasag,M. Zuk,Jolanta Kubalska,Agnieszka Węgrzyn,Małgorzata Bednarska-Makaruk,Ewa Pronicka,Hanna Wehr,J.C. Defesche,Andrzej Rynkiewicz,Janusz Limon +10 more
TL;DR: The findings imply that major rearrangements of theLDLR gene as well as 2 point mutations are frequent causes of ADH in Poland, and the heterogeneity ofLDLR mutations detected in the studied group confirms the requirement for complex molecular studies of Polish ADH patients.
Journal ArticleDOI
Detection of somatic BRCA1/2 mutations in ovarian cancer – next‐generation sequencing analysis of 100 cases
Magdalena Koczkowska,M. Zuk,Adam Gorczyński,Magdalena Ratajska,Marzena Anna Lewandowska,Wojciech Biernat,Janusz Limon,Bartosz Wasag +7 more
TL;DR: The heterogeneity of the detected mutations confirms the necessity of simultaneous analysis of BRCA1/2 genes in all patients diagnosed with serous ovarian carcinoma, and the use of tumor tissue for mutational analysis allowed the detection of both somatic and germline BRC
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Efficacy of clinical diagnostic criteria for familial hypercholesterolemia genetic testing in Poland
Agnieszka Mickiewicz,Magdalena Chmara,Marta Futema,Marcin Fijałkowski,Krzysztof Chlebus,Rafal Galaska,Tomasz Bandurski,Marcin Pajkowski,M. Zuk,Bartosz Wasag,Janusz Limon,Andrzej Rynkiewicz,Marcin Gruchała +12 more
TL;DR: The study validated the efficacy of proposed clinical FH criteria for the disease diagnosis in Poland and proposed that in the healthcare systems with limited genetic testing resources individuals younger than 40 years, who fulfill the clinical criteria for possible, probable or definite FH should qualify for the FH mutation testing.
Journal ArticleDOI
Molecular basis of familial hypercholesterolemia in Poland – update from the Polish national centre of diagnostics and treatment of familial hypercholesterolemia
M. Chmara,M. Zuk,Agnieszka Mickiewicz,Agnieszka Brandt,Krzysztof Chlebus,Jolanta Kubalska,Joanna Bautembach-Minkowska,M. Stroniawska-Woźniak,Małgorzata Bednarska-Makaruk,Longina Kłosiewicz-Latoszek,Andrzej Rynkiewicz,Malgorzata Mysliwiec,Marcin Gruchała,Janusz Limon,Bartosz Wasag +14 more