The invention discloses a chemical synthesizing method of ozagrel. The method comprises the following steps: carrying out a free radical reaction on p-tolualdehyde and 1, 3-dibromo-5, 5-dimethylhydantoin (DBDMH) in an organic solvent under the effect of an initiator at 40-90 DEG C to obtain 4-bromo methyl benzaldehyde; then, carrying out a reaction on 4-bromo methyl benzaldehyde and imidazole in a dipolar aprotic solvent at a room temperature under the effect of an accelerant to obtain 4-(1-imidazole methyl) benzaldehyde; and carrying out a reaction on 4-(1-imidazole methyl) benzaldehyde and acetic anhydride in an eutecticevaporate solvent to obtain ozagrel. Compared with conventional synthetic methods, the method disclosed by the invention is available in raw materials and low in cost of raw materials, short in reaction step, free from column chromatography isolation, low in preparation method and less in three-waste emission. The method disclosed by the invention is suitable for industrially producing ozagrel.

Ma Cuili

Papers

Chemical synthesizing method of ozagrel