M
Maciek R. Antoniewicz
Researcher at University of Delaware
Publications - 93
Citations - 7954
Maciek R. Antoniewicz is an academic researcher from University of Delaware. The author has contributed to research in topics: Metabolic flux analysis & Pentose phosphate pathway. The author has an hindex of 47, co-authored 89 publications receiving 6638 citations. Previous affiliations of Maciek R. Antoniewicz include Massachusetts Institute of Technology & University of Michigan.
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Metabolic network reconstruction, growth characterization and 13C-metabolic flux analysis of the extremophile Thermus thermophilus HB8.
TL;DR: It is found that T. thermophilus largely uses glycolysis and TCA cycle to produce biosynthetic precursors, ATP and reducing equivalents needed for cells growth, which is consistent with its proposed metabolic network model.
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13C metabolic flux analysis of the extremely thermophilic, fast growing, xylose-utilizing Geobacillus strain LC300
TL;DR: The pentose phosphate pathway, glycolysis and TCA cycle were found to be highly active in Geobacillus LC300 and contributed significantly to NADPH production and transhydrogenase activity was detected.
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Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway.
TL;DR: These studies provide the first test of multivariate regression models for the analysis of isotopomer flux data and provide insight for metabolomics and the future of isotopic tracers in metabolic research where the underlying physiology is complex or unknown.
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Evidence for transketolase-like TKTL1 flux in CHO cells based on parallel labeling experiments and (13)C-metabolic flux analysis.
TL;DR: This study demonstrates for the first time that carbon atoms can be lost in the PPP, by means other than the oxidative P PP, and that this loss of carbon atoms is consistent with the hypothesized TKTL1 reaction in mammalian cells.
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Metabolism in dense microbial colonies: 13C metabolic flux analysis of E. coli grown on agar identifies two distinct cell populations with acetate cross-feeding
TL;DR: This study investigated for the first time the metabolism of E. coli grown on agar using 13C metabolic flux analysis (13C-MFA) and identified new optimal 13C tracers to quantify fluxes in systems where the acetate yield cannot be easily measured, providing a solid foundation for future investigations of a wide range of problems involving microbial biofilms.