Showing papers by "Maja-Lisa Løchen published in 2001"
TL;DR: Women were more likely than men to remain in the upper sextile of systolic and diastolic blood pressures and of BMI, and some baseline predictors were associated with tracking, but the effects were relatively weak.
Abstract: Tracking of cardiovascular risk factors (blood pressure, body mass index (BMI), and serum lipids) has not been studied much in a general, adult population. No known study has compared tracking of these factors for both sexes. In the present study, 17,710 men and women aged 20-61 years at baseline attended two or three population-based health surveys in Tromso, Norway, over 16 years (between 1979-1980 and 1994-1995). Tracking coefficients were estimated by using different methods, and possible predictors of tracking were found. There was a high degree of tracking for BMI (overall tracking coefficients: 0.85 for men, 0.80 for women). Relatively high (or moderate) tracking was found for systolic blood pressure (respective sex-specific coefficients: 0.52, 0.54), diastolic blood pressure (0.48, 0.48), high density lipoprotein cholesterol (0.55, 0.64), and total cholesterol (0.77, 0.65). The lowest coefficients were for triglycerides (0.43, 0.39). Analysis of tracking in the upper sextile confirmed these results. Although some baseline predictors were associated with tracking, the effects were relatively weak. When predictors for tracking in the upper sextile were assessed, significant associations were found with relatively strong effects. No major sex differences were observed in tracking. However, women were more likely than men to remain in the upper sextile of systolic and diastolic blood pressures and of BMI.
101 citations
TL;DR: Body mass index increased in every examined birth cohort (1925-1964) during the 15- to 20-year observation period and primary prevention of further increased body weight should be a priority.
Abstract: Background Obesity is a risk factor for a number of chronic diseases. Few longitudinal studies have examined changes in body mass index (BMI [calculated as weight in kilograms divided by the square of the height in meters]). Objective To investigate the changes in mean BMI and the prevalence of obesity in a large cohort examined several times during a 20-year period. Methods Mean BMI, the percentage of subjects with low BMI ( 2 ), and the percentage who were obese (BMI ≥30 kg/m 2 ) were determined in a large population of men and women who were examined up to 4 times during a 20-year period (1974-1994/1995). In a longitudinal design, we observed 3541 men who attended all 4 screenings (1974-1994/1995) and 4993 women who attended the last 3 screenings (1979/1980-1994/1995). Results The age- (25-49 years) and sex-adjusted mean BMI increased 1 kg/m 2 in men from 1974 to 1994/1995 and 0.9 kg/m 2 in women from 1979/1980 to 1994/1995. In the last survey, subjects aged 25 to 85 years were included. In most age groups, the mean BMI exceeded 25 kg/m 2 and the prevalence of obesity was 10% or higher in men and women aged 45 years or older. In the longitudinal analysis, the mean BMI in men aged 20 to 49 years increased 2.0 kg/m 2 during 20 years of observation and increased 2.4 kg/m 2 in women aged 20 to 49 years during 15 years of observation. The increase in BMI was larger in younger men than in older men. Conclusions Body mass index increased in every examined birth cohort (1925-1964) during the 15- to 20-year observation period. Primary prevention of further increased body weight should be a priority.
83 citations
Journal Article•
TL;DR: Normalisation of haematopoiesis after cortisol substitution indicates that cortisol plays an important role in the regulation of haenorrhage regulation in patients with primary empty sella syndrome with isolated ACTH cortisol deficiency.
Abstract: BACKGROUND A 64-year-old man was admitted to our hospital with significant weight loss and symptoms of fatigue. He had normocytic anaemia and absolute neutropenia in peripheral blood. MATERIAL AND METHODS Further haematological and endocrinological investigations were performed. RESULTS Bone marrow aspiration and biopsy showed dysplastic signs. Immunophenotyping and cytogenetics did not provide evidence of primary haematological disease. Endocrinological testing demonstrated secondary adrenal insufficiency. Magnetic resonance imaging of the sella turcica showed an empty sella. Cortisol substitution eliminated the symptoms of the patient and normalised his peripheral blood values. The disturbed maturity and hypoplasia of the bone marrow were also normalised. INTERPRETATION Normalisation of haematopoiesis after cortisol substitution indicates that cortisol plays an important role in the regulation of haematopoiesis. Primary empty sella syndrome with isolated ACTH cortisol deficiency is a very rare cause of disturbed haematopoiesis.
2 citations