Showing papers by "Majid Eslami published in 2023"
TL;DR: The role of non-coding RNAs (lncRNAs) and microRNAs (miRNAs), in the diagnosis and treatment of different stages of hepatitis B infection is discussed in this paper .
2 citations
2 citations
TL;DR: In this paper , the authors summarized the therapeutic application of IL-35 and IL-37 in both human and experimental models of IBD and showed that these anti-inflammatory cytokines have significant potential to reduce intestinal inflammation.
1 citations
1 citations
DOI•
16 Mar 2023
TL;DR: In this paper , a total of 100 E. coli isolates were collected from septicemic patients and the antibiotic susceptibility testing was conducted with disk diffusion method and the prevalence of CTX-M gene and presence of insertion elements IS26 (IS26a and IS26b) and ISEcp1 were investigated.
Abstract: Introduction: Septicemia is a significant infection caused by some agents such as Escherichia coli. The goal of this study was to see how effective antibiotics were against E. coli isolates from septicemia patients, as well as to look into their genetic relationship. Materials and Methods: A total of 100 E. coli isolates were collected from septicemic patients. The antibiotic susceptibility testing was conducted with disk diffusion method. The prevalence of CTX-M gene and presence of insertion elements IS26 (IS26a and IS26b) and ISEcp1 were investigated. Phylogrouping, serogrouping and virulence typing were also investigated. The pulsed-field gel electrophoresis (PFGE) was also performed for genetic classification. Results: Fifty-one CTX-M positive isolates were identified. There was no resistance to phosphomycin. The ISEcp1, IS26a, and IS26b were detected in upstream of 84.3%, 5.8% and 9.8% of CTX-M, respectively. The orf477 was detected downstream of all CTX-M positive isolates. Thirty-six isolates belonged to the B2 phylogroup, followed by 25 D, 22 A, and 17 B1. The most frequent serogroup in the isolates is O1 serogroup. The highest rate of virulence genes included csgA, traT, iutA, hlyA, and kpsMII. The results of PFGE showed five clusters (A–E) using 80% cut-off. Conclusion: A significant relation between CTX-M gene and virulence factors was determined. Hence, surveillance and proper control strategies are essential to prevent the distribution virulent and drug-resistant E. coli. Although phosphomycin was found to be effective in eradicating extended spectrum β-lactamases-producing E. coli infections in septicemic patients, no genetic relationships between isolates were discovered.
TL;DR: In this article , the authors provide an overview of the most significant research findings based on proteomics and biosensors for the diagnosis of Glioblastoma multiform (GBM).
Abstract: Glioblastoma (GBM) is an aggressive type of cancer that originates in the cells called astrocytes, which support the functioning of nerve cells. It can develop in either the brain or the spinal cord and is also known as glioblastoma multiform. GBM is a highly aggressive cancer that can occur in either the brain or spinal cord. The detection of GBM in biofluids offers potential advantages over current methods for diagnosing and treatment monitoring of glial tumors. Biofluid-based detection of GBM focuses on identifying tumor-specific biomarkers in blood and cerebrospinal fluid. To date, different methods have been used to detect biomarkers of GBM, ranging from various imaging techniques to molecular approaches. Each method has its own strengths and weaknesses. The present review aims to scrutinize multiple diagnostic methods for GBM, with a focus on proteomics methods and biosensors. In other words, this study aims to provide an overview of the most significant research findings based on proteomics and biosensors for the diagnosis of GBM.