Marcus Miethke

TL;DR: General aspects of siderophore-mediated iron acquisition, recent findings regarding iron-related pathogen-host interactions, and current strategies for iron-dependent pathogen control will be reviewed.

TL;DR: By interfering with iron-sulfur cluster formation, copper stress leads to enhanced expression of cluster scaffold and target proteins as well as iron and sulfur acquisition pathways, suggesting a possible feedback strategy to reestablish cluster biogenesis.

TL;DR: It is shown that ferri‐BB uptake is mediated by the FeuABC transporter and that YuiI, a novel trilactone hydrolase, catalyses ferri •BB hydrolysis leading to cytosolic iron release and was the preferred substrate of the Yuii esterase whose gene locus was designated besA.

TL;DR: Ca isotope labeling demonstrated that sequestered Cu+ became bio-available for the synthesis of plastocyanin, and transcriptome profiling indicated that mobilized Cu became visible to CRR1, and Cu trafficking to intracellular accumulation sites may be a strategy for preventing protein mis- metallation during Zn deficiency and enabling efficient cuproprotein (re)-metallation upon Zn resupply.

TL;DR: Several iron channeling routes have been described recently and provide first insights into the later steps of iron assimilation that characterize an essential part of the cellular iron homeostasis network.