Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.

Biological and Phytochemical Screening of Plants

https://www.jacionline.org/article/S0021-8707(68)90117-2/pdf

The beta adrenergic theory of the atopic abnormality in bronchial asthma

In this chapter, we discuss the diseases and related pathologic alterations that may be encountered in the gastrointestinal tract and associated organs of various species of laboratory animals, birds, fish, reptiles, and amphibians. Diseases of various segments of the gastrointestinal tract, the salivary glands, liver, and pancreas are discussed and categorized as inflammatory, parasitic, neoplastic, or miscellaneous. The latter category includes developmental anomalies and metabolic lesions. Due to space limitations, this presentation is not an all-inclusive review, but it does provide a rather extensive review of these lesions. We have also included a rather comprehensive literature review, with a list of references for those readers who want more detailed information with respect to specific diseases.

The Digestive System

Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies and is broadly generalizable as being independent of chemical/physical agent, biological model, and endpoint measured. This under-recognized and -appreciated concept has the potential to profoundly change toxicology and its related disciplines with respect to study design, animal model selection, endpoint selection, risk assessment methods, and numerous other aspects, including chemotherapeutics. This article indicates that as a result of hormesis, fundamental changes in the concept and conduct of toxicology and risk assessment should be made, including (a) the definition of toxicology, (b) the process of hazard (e.g., including study design, selection of biological model, dose number and distribution, endpoint measured, and temporal sequence) and risk assessment [e.g., concept of NOAEL (no observed adverse effect level), low dose modeling, recognition of beneficial as well as harmful responses] for all agents, and (c) the harmonization of cancer and noncancer risk assessment.

/pdf/hormesis-the-dose-response-revolution-2zuasit662.pdf

Hormesis: The Dose-Response Revolution

The Biological Effects and the Chemical Composition of Podophyllin. A Review

Appearance and persistence of fluorescent material in tumor tissue after tetracycline administration.

Neoplasms of the hematopoietic system in nonhuman primates: report of one spontaneous tumor and two leukemias induced by procarbazine.

Comparative Carcinogenicity of N-Isopropyl-α-(2-Methylhydrazino)-p-Toluamide · HCI (Procarbazine Hydrochloride), Its Degradation Products, Other Hydrazines, and Isonicotinic Acid Hydrazide

Margaret G. Kelly

Papers

The Biological Effects and the Chemical Composition of Podophyllin. A Review

Appearance and persistence of fluorescent material in tumor tissue after tetracycline administration.

Neoplasms of the hematopoietic system in nonhuman primates: report of one spontaneous tumor and two leukemias induced by procarbazine.

Comparative Carcinogenicity of N-Isopropyl-α-(2-Methylhydrazino)-p-Toluamide · HCI (Procarbazine Hydrochloride), Its Degradation Products, Other Hydrazines, and Isonicotinic Acid Hydrazide

Effect of Caloric Restriction on Mammary-Tumor Formation in Strain C3H Mice and on the Response of Strain DBA to Painting with Methylcholanthrene