Maria Antonietta Sanfratello

TL;DR: Real time PCR analysis showed a prompt expression induced by LPS inoculation suggesting that the C. intestinalis IL-17 genes share a common ancestor in the chordate lineages suggesting that they are involved in the first phase of inflammatory response.

TL;DR: In sea bass, cortisol intraperitoneal injection and in vitro treatment of head kidney cells show that inducible Hsp70 and Hsp90 are modulated by this hormone, but an inverse relationship between mRNA expression and Hsps synthesis levels was found and time-course assays indicate a cortisol-mediated regulation.

TL;DR: In situ hybridisation and immunohistochemistry analyses have shown that the Ciona intestinalis tumour necrosis factor alpha gene (CiTNFα), which has been previously cloned and sequenced, is expressed either during the inflammatory pharynx response to lipopolysaccharide (LPS) or during the swimming larval phase of development.

TL;DR: Although sea bass head kidney expressed both Dl GR1 and DlGR2 they were differentially modulated by intraperitoneal implant of exogeneous cortisol, mimicking stress effects.

TL;DR: A novel attempt was carried out on CiLgals-a and -b CRDs phylogenetic analysis, and their involvement in ascidian inflammatory responses was shown, and sequence similarity between clusters suggests an evolutionary model based on CRD domain gene duplication and sequence diversification.