M
Maria C. Buniel
Researcher at Northwestern University
Publications - 6
Citations - 2002
Maria C. Buniel is an academic researcher from Northwestern University. The author has contributed to research in topics: Synapse & Dendritic spine. The author has an hindex of 3, co-authored 6 publications receiving 1869 citations.
Papers
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Journal ArticleDOI
Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease
Pascale N. Lacor,Maria C. Buniel,Paul W. Furlow,Antonio Sanz Clemente,Pauline T. Velasco,Margaret Wood,Kirsten L. Viola,William L. Klein +7 more
TL;DR: The observed disruption of dendritic spines links ADDLs to a major facet of AD pathology, providing strong evidence that AD DLs in AD brain cause neuropil damage believed to underlie dementia.
Journal ArticleDOI
Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
Pascale N. Lacor,Maria C. Buniel,Lei Chang,Sara J. Fernandez,Yuesong Gong,Kirsten L. Viola,Mary P. Lambert,Pauline T. Velasco,Eileen H. Bigio,Caleb E. Finch,Grant A. Krafft,William L. Klein +11 more
TL;DR: The hypothesis that targeting and functional disruption of particular synapses by Aβ oligomers may provide a molecular basis for the specific loss of memory function in early Alzheimer's disease is suggested.
Patent
Compositions Comprising Addl Receptors, Related Compositions, and Related Methods
Pascale N. Lacor,Kirsten L. Viola,Mary P. Lambert,Yeusong Gong,Lei Chang,Pauline T. Velasco,Eileen H. Bigio,Maria C. Buniel,Sara J. Fernandez,Jasna Jerecic,Susan Catalano,Todd Pray,Ray Lowe,Grant A. Krafft,William L. Klein +14 more
TL;DR: In this paper, compositions comprising ADDL receptors, related compositions, and related methods are disclosed and claimed, including procedures to screen for compounds that affect, either positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise.
Journal ArticleDOI
P3-319 Synaptic targeting by Alzheimer's related abeta oligomers
Patent
Compositions contenant des recepteurs d'addl, compositions et methodes associees
Pascale N. Lacor,Kirsten L. Viola,Mary P. Lambert,Yuesong Gong,Lei Chang,Pauline T. Velasco,Eileen H. Bigio,Maria C. Buniel,Sara J. Fernandez,Jasna Jerecic,Susan Catalano,Todd Pray,Ray Lowe,Grant A. Krafft,William L. Klein +14 more
TL;DR: The authors concerne des compositions contenant des recepteurs d'ADDL, ainsi que des compositions and des methodes associees, contiennent, entre autres, des composes qui modifient, positivement ou negativement, the liaison des ADDL aux cellules neuronales, soit par l'intermediaire d'au moins un recepteur localise au niveau de la densite postsynaptique (PSD) soit autrement.