M
María Gutiérrez-Fernández
Researcher at Autonomous University of Madrid
Publications - 50
Citations - 1938
María Gutiérrez-Fernández is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Stroke & Mesenchymal stem cell. The author has an hindex of 19, co-authored 48 publications receiving 1530 citations. Previous affiliations of María Gutiérrez-Fernández include Hospital Universitario La Paz.
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Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke
María Gutiérrez-Fernández,Berta Rodríguez-Frutos,Jaime Ramos-Cejudo,M Teresa Vallejo-Cremades,Blanca Fuentes,Sebastián Cerdán,Exuperio Díez-Tejedor +6 more
TL;DR: Allogenic MSC administration in pMCAO infarct was associated with good functional recovery, and reductions in cell death as well as increases in cellular proliferation, neurogenesis, oligodendrogenesis, synaptogenesis and angiogenesis markers at 14 days post-infarct.
Journal ArticleDOI
White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke
Laura Otero-Ortega,Fernando Laso-García,María del Carmen Gómez-de Frutos,Berta Rodríguez-Frutos,Jorge Pascual-Guerra,Blanca Fuentes,Exuperio Díez-Tejedor,María Gutiérrez-Fernández +7 more
TL;DR: It is found that a single administration of EVs improved functional recovery, fiber tract integrity, axonal sprouting and white matter repair markers in an experimental animal model of subcortical stroke and presents a new perspective in the development of biologics for brain repair.
Journal ArticleDOI
Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats.
María Gutiérrez-Fernández,Berta Rodríguez-Frutos,J. Álvarez-Grech,María Teresa Vallejo-Cremades,M. Expósito-Alcaide,J. Merino,J.M. Roda,Exuperio Díez-Tejedor +7 more
TL;DR: It is concluded that allogenic MSCs administration shows therapeutic efficacy in the acute ischemic stroke model and both routes demonstrably improved neurological recovery and provided brain protection.
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Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage
Laura Otero-Ortega,Mari Carmen Gómez-de Frutos,Fernando Laso-García,Berta Rodríguez-Frutos,Esperanza Medina-Gutiérrez,Juan Antonio López,Jesús Vázquez,Exuperio Díez-Tejedor,María Gutiérrez-Fernández +8 more
TL;DR: Animals receiving treatment with exosomes showed significantly better results in terms of functional recovery, lesion size, fiber tract integrity, axonal sprouting and white matter repair markers compared with the control group 28 days after stroke.
Journal ArticleDOI
Brain-Derived Neurotrophic Factor Administration Mediated Oligodendrocyte Differentiation and Myelin Formation in Subcortical Ischemic Stroke
Jaime Ramos-Cejudo,María Gutiérrez-Fernández,Laura Otero-Ortega,Berta Rodríguez-Frutos,Blanca Fuentes,María Teresa Vallejo-Cremades,Teresa Navarro Hernanz,Sebastián Cerdán,Exuperio Díez-Tejedor +8 more
TL;DR: BDNF administration exerted better functional outcome, oligodendrogenesis, remyelination, and fiber connectivity than controls in rats subjected to subcortical damage in ischemic stroke.