María José Bellini

TL;DR: It is indicated that prenatal stress induces a basal proinflammatory status in the hippocampal formation during adulthood that results in an enhanced activation of microglia and astrocytes in response to a proinflammatory insult.

TL;DR: Male and female cortical astrocytes respond differentially to an inflammatory challenge and this may be predetermined by perinatal testosterone exposure.

TL;DR: Treatment with tamoxifen and raloxifene resulted in a significant reduction of the number of reactive astrocytes in the hippocampus of young, middle‐aged and older female rats after a stab wound injury, suggesting that oestrogenic compounds are candidates to counteract brain inflammation under neurodegenerative conditions by targeting the production and release of pro‐inflammatory molecules by glial cells.

TL;DR: IGF-I gene therapy may represent a new approach to reduce inflammatory reactions in glial cells and decreased lipopolysaccharide-induced translocation of nuclear factor κB to the cell nucleus.

TL;DR: It is suggested that estradiol may decrease reactive astroglia in the injured brain by regulating the activity of the endocannabinoid system.