M
María Salud García-Gutiérrez
Researcher at Universidad Miguel Hernández de Elche
Publications - 63
Citations - 2499
María Salud García-Gutiérrez is an academic researcher from Universidad Miguel Hernández de Elche. The author has contributed to research in topics: Cannabinoid & Cannabinoid receptor. The author has an hindex of 25, co-authored 52 publications receiving 1799 citations. Previous affiliations of María Salud García-Gutiérrez include Spanish National Research Council & Carlos III Health Institute.
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Journal ArticleDOI
Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection.
Juan G. Zarruk,David Fernández-López,Isaac García-Yébenes,María Salud García-Gutiérrez,José Vivancos,Florentino Nombela,Magdalena Torres,María C. Burguete,Jorge Manzanares,Ignacio Lizasoain,María A. Moro +10 more
TL;DR: The inhibitory effect of CB2R on the activation of different subpopulations of microglia/macrophages may account for the protective effect of the selectiveCB2R agonist JWH-133 after stroke.
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Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice
A. Ortega-Alvaro,Auxiliadora Aracil-Fernández,Auxiliadora Aracil-Fernández,María Salud García-Gutiérrez,María Salud García-Gutiérrez,Francisco Navarrete,Francisco Navarrete,Jorge Manzanares,Jorge Manzanares +8 more
TL;DR: The results suggest that deletion of CB2r has a relation with schizophrenia-like behaviors and Pharmacological manipulation ofCB2r may merit further study as a potential therapeutic target for the treatment of schizophrenia-related disorders.
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Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
TL;DR: It is revealed that increased expression of CB2r significantly reduced anxiogenic-related behaviours, modified the response to stress and impaired the action of anxiolytic drugs.
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Chronic blockade of cannabinoid CB2 receptors induces anxiolytic‐like actions associated with alterations in GABAA receptors
María Salud García-Gutiérrez,María Salud García-Gutiérrez,Borja García-Bueno,Silvia Zoppi,Juan C. Leza,Jorge Manzanares,Jorge Manzanares +6 more
TL;DR: The aim of this study was to explore the effects of CB2 receptor agonist and antagonist in the regulation of anxiety‐like behaviours and to establish a causal relationship between CB2 receptors and anxiety-like behaviours.
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Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects.
Eva M. Marco,María Salud García-Gutiérrez,Francisco Javier Bermúdez-Silva,Fabrício A. Moreira,Francisco V.A. Guimarães,Jorge Manzanares,Maria-Paz Viveros +6 more
TL;DR: The eCB system plays a critical role in psychiatry; however, detrimental consequences of manipulating this endogenous system cannot be underestimated over the potential and promising perspectives of its therapeutic manipulation.