M
Maria Segarra-Queralt
Publications - 2
Citations - 7
Maria Segarra-Queralt is an academic researcher. The author has contributed to research in topics: Osteoarthritis & Chondrocyte. The author has an hindex of 2, co-authored 2 publications receiving 7 citations.
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Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments
Maria Segarra-Queralt,Michael Neidlin,Laura Tío,Jordi Monfort,Joan Carles Monllau,Miguel Ángel González Ballester,Leonidas G. Alexopoulos,Gemma Piella,Jérôme Noailly +8 more
TL;DR: In this paper , a network-based model at the chondrocyte level was proposed to enable the semiquantitative interpretation of the intricate mechanisms of osteoarthritis progression, incorporating the complex ways in which inflammatory factors affect structural protein and protease expression and nociceptive signals.
Journal ArticleDOI
Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis
TL;DR: In this paper , a mechano-sensitive network-based model for chondrocyte activity is proposed, in the form of a continuous dynamical system: an interactome of a set of 118 nodes, i.e., mechanosensitive cellular receptors, second messengers, transcription factors and proteins, related among each other through a specific topology of 358 directed edges.