Maria Victoria Marcos

TL;DR: The timing of menarche and the level of final height in Catalan girls with early onset of puberty was found to depend on prenatal growth, and if these findings are confirmed in other ethnic and/or larger groups, then a subgroup has been identified that will most likely benefit from any therapeutic intervention aiming at a delay of pubertal development and/ or an increase offinal height.

TL;DR: Serum DHEAS, androstenedione and insulin concentrations were determined together with fasting glycemia in matched populations of asymptomatic, non-obese, post-menarcheal girls to test the hypothesis that prenatal growth reduction is followed by exaggerated adrenarche.

TL;DR: Observations corroborate the idea that insulin resistance may indeed be a prime factor underpinning the sequence from reduced fetal growth, through precocious pubarche, to adolescent endocrinopathies that are reminiscent of so-called polycystic ovary syndrome and reduced hyperinsulinemia, hirsutism, and hyperandrogenism.

TL;DR: Shorter androgen receptor gene CAG number, indicative of increased androgen sensitivity, increases risks for PP and subsequent ovarian hyperandrogenism, and shorter CAG repeat alleles in Barcelona compared with United Kingdom women could lead to higher prevalences of these conditions.

TL;DR: In conclusion, sensitization to insulin was found to be an effective approach to induce ovulation in nonobese adolescents with anovulatory hyperandrogenism.