One of the manifestations of gastroesophageal reflux disease (GERD) is extraesophageal symptoms, in particular, from the upper and lower respiratory tract. Gastroesophageal reflux is capable of both causing respiratory symptoms independently and aggravating the course of already existing diseases of the respiratory system. The article presents available in the literature current information on the pathogenesis of GERD respiratory symptoms, their clinical course, considerations of diagnosis and treatment.

https://ter-arkhiv.ru/0040-3660/article/download/32830/pdf

On respiratory manifestations of gastroesophageal reflux disease.

Purpose . To evaluate the results of the application of allogenic fibroblasts in patients with extensive thermal burns. Methods . The study included 34 patients with burns over 20% TBSA, treated in the burn ICU. In accordance with the indications for transplantation of fibroblasts, all patients were divided into 4 groups: stimulation of regeneration of superficial burns (n = 10), stimulation of regeneration after meshed skin graft (n = 14), reduction of healing time for donor wounds (n = 6) and acceleration growth of granulations after the escharectomy (n = 4). Results . A positive effect of fibroblast transplantation was found in 7 (70%) patients of the first group, 13 (93%) patients of the second group, 2 (33%) patients of the third group and 2 (50%) patients of the fourth study group. Conclusion . The maximum positive effect of transplantation of human dermal fibroblasts can be observed when performing the meshed skin graft and treating the superficial burns.

https://journals.eco-vector.com/vszgmu/article/viewFile/9072/8217

Experience in the clinical use of allogeneic fibroblasts in patients with severe burns

The article analyzes the results of treating 545 elderly and senile patients with complicated forms of colon cancer and severe concomitant pathology. Depending on the method of surgical treatment, the patients were divided into two groups. The control group consisted of 408 patients, who were performed traditional surgery without investigating the Tei index. The patients of the main group were operated using endovideosurgical technologies. In addition, the calculation of systolic-diastolic ratio by means of Doppler echocardiography was carried out. Measuring the Tei index allowed correcting cardiovascular risk in the perioperative period, thereby increasing operability and reducing the number of postoperative cardiac complications. The use of minimally invasive methods of surgical treatment for colon cancer contributed to a decrease in the frequency of postoperative complications. Thus, it contributed to reducing hospital mortality from 29.9% to 2.2%.

/pdf/ways-to-improve-the-immediate-results-of-treating-3xbrgbzh0g.pdf

Ways to improve the immediate results of treating complicated colon cancer in elderly and senile patients

Recent achievements in many sciences have led to an understanding of the need to form new ideas about the nature of human relationships with the environment and the inner world, his health, the principles of disease formation and their prevention. There has been a transition from a collection of achievements of various sciences to a holistic paradigm that unites a person as an organism and as a person, his inner and surrounding world. It became obvious that this could not be done within the framework of the previous general theories of medicine. To this end, the authors propose a new theory of medicine: "the theory of noospheric-anthropogenic harmony". From the standpoint of this theory, the mechanisms of the relationship of microbiota and pathogens with the protective and acceptive immunity of a healthy and sick person, as well as the mechanisms of microbiota regulation, are considered. The paradigm of dysbiosis as the cause of many diseases and main homeostatic mechanisms that provide symbiotic relationships of microbiota, immunity and its role in the mechanisms of natural tolerance and formation of various disease, such as, autoimmune ones and tumors, require a change in the acceptedtreatment and prevention. A new approach should be based on using a new class of drugs — metabiotics, which in their term influence microbiota.

/pdf/disease-as-a-result-of-violations-of-the-symbiotic-13r1w0ajj9.pdf

Disease as a result of violations of the symbiotic relationship between the host and the microbiota with pathogens

INTRODUCTION. About 75% of patients with Crohn's disease (CD) required surgery due to the complications of CD. Surgical treatment does not cure this disease. The question of appropriate therapy for the prevention of postoperative reccurence of CD remains open until now. The purpose of this study was to compare immunosuppressive and biological therapy as a postoperative preventive therapy. MATERIALS AND METHODS. 91 patients with CD who underwent surgery in the A.N. Ryzhykh State Scientific Center for Coloproctology of the Ministry of Health of Russian Federation from 2010 to 2017 were included in the study. Patients who had inflammation in the remaining areas of the intestine in the outcome of surgical treatment were excludedfrom the study. After surgery, patients were randomized into 3 groups. In the first group preventive therapy was carried out with azathioprine, in the second group with adalimumab, in the third group, patients received combination therapy with azathioprine and adalimumab. Clinical, endoscopical and laboratory assessment of disease activity was conducted at 3, 6 and 12 month after the surgery. RESULTS. During one year of preventive therapy with azathioprine, adalimumab, or a combination of this medications, relapse occurred in 17 patients (17/83, 20%). There were no statistically significant differences between the groups in any of the stages of evaluation. CONCLUSION: The data obtained in the study allow to conclude that the frequency of relapses of CD on postoperative preventive therapy does not depend on the specific drug, as well as on demographic and anamnestic parameters.

/pdf/the-efficiency-of-postoperative-preventive-treatment-by-8x1ei7xz3y.pdf

Marina A. Podrezova

Papers

Информационное обеспечение науки и образования в Научной библиотеке ОНУ имени И. И. Мечникова