M
Mario D. Galigniana
Researcher at Instituto de Biología y Medicina Experimental
Publications - 105
Citations - 5696
Mario D. Galigniana is an academic researcher from Instituto de Biología y Medicina Experimental. The author has contributed to research in topics: Hsp90 & Immunophilins. The author has an hindex of 40, co-authored 99 publications receiving 5257 citations. Previous affiliations of Mario D. Galigniana include Fundación Instituto Leloir & University of Michigan.
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Journal ArticleDOI
Mechanism of action of the potent sodium-retaining steroid 11, 19-oxidoprogesterone.
Mario D. Galigniana,Guillermo P. Vicent,Graciela Piwien-Pilipuk,Gerardo Burton,Carlos P. Lantos +4 more
TL;DR: Both the pharmacokinetic properties of 11,19-oxidoprogesterone and its ability to transform and translocate the MR into the nucleus are undistinguishable from aldosterone.
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Molecular Chaperone Activity and Biological Regulatory Actions of the TPR-Domain Immunophilins FKBP51 and FKBP52
TL;DR: FKBP51 and FKBP52 were first characterized due to their ability to interact with steroid hormone receptors and their potential as pharmacologic targets are reviewed.
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Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90.
Gisela Ileana Mazaira,Cristina Daneri-Becerra,Nadia R Zgajnar,Cecilia M Lotufo,Mario D. Galigniana,Mario D. Galigniana +5 more
TL;DR: Various aspects of the regulatory action of HSF1 and Hsp90 on transcriptional regulation are discussed, and how this regulation may affect genetic assimilation mechanisms and the health of individuals are discussed.
Journal ArticleDOI
Hsp90-binding immunophilins as a potential new platform for drug treatment
TL;DR: The emerging role of immunophilins in protein transport, transcription regulation, malignancies development and neurotrophic action, in addition to a number of biological properties that transform these proteins in potential targets for novel therapeutic strategies are reviewed.
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Regulation of FKBP51 and FKBP52 functions by post-translational modifications
Cristina Daneri-Becerra,Nadia R Zgajnar,Cecilia M Lotufo,Ana B Ramos Hryb,Graciela Piwien-Pilipuk,Mario D. Galigniana,Mario D. Galigniana +6 more
TL;DR: Recent advances in the study of these immunophilins are summarized portraying them as scaffolding proteins capable to organize protein heterocomplexes, describing some of their antagonistic properties in the physiology of the cell, and the putative regulation of their properties by those post-translational modifications.