M
Mark Eastwood
Researcher at University of Westminster
Publications - 47
Citations - 4065
Mark Eastwood is an academic researcher from University of Westminster. The author has contributed to research in topics: Extracellular matrix & Fibroblast. The author has an hindex of 33, co-authored 47 publications receiving 3915 citations. Previous affiliations of Mark Eastwood include University of Western Ontario & University College London.
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Journal ArticleDOI
Tensional homeostasis in dermal fibroblasts: mechanical responses to mechanical loading in three-dimensional substrates
TL;DR: This is the first detailed characterisation of a tensional homeostatic response in cells, and it is shown that increased external loading was followed immediately by a reduction in cell‐mediated contraction whilst decreased external loading elicited increased contraction.
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Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Xu Shiwen,Yunliang Chen,Christopher P. Denton,Mark Eastwood,Elisabetta A. Renzoni,George Bou-Gharios,Jeremy D. Pearson,Michael R. Dashwood,Roland M. du Bois,Carol M. Black,Andrew Leask,David Abraham +11 more
TL;DR: It is shown that addition of ET-1 to normal lung fibroblasts induces expression of proteins that contribute to a contractile phenotype, including alpha-smooth muscle actin (alpha-SMA), ezrin, moesin, and paxillin, which might be beneficial in reducing scar formation in pulmonary fibrosis.
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Effect of precise mechanical loading on fibroblast populated collagen lattices: morphological changes.
TL;DR: This study has shown that the resident fibroblast population will respond to changes in strain resulting from the most subtle of mechanical loads, which may be an important mechanism in development and repair of connective tissue.
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Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and the relationship to cell morphology
TL;DR: Comparison of the contraction profiles of cells extracted from other tissues (tendon and articular cartilage), and extracted by different means from the same tissue specimen, indicated that different populations of fibroblasts can be distinguished on the basis of their pattern of contractions.
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A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling
TL;DR: Cell force responses during the initial and linear phases indicated that contraction of the cells responded in a rapid and subtle manner to changes in the mechanical properties of their substrate.