Design and construction of an artificial pathway for biosynthesis of acetaminophen in Escherichia coli.

Provided is a microorganism that is capable of efficiently producing para-aminobenzoic acid (4-ABA) or a salt thereof, using saccharides as raw materials, and a method for efficiently producing 4-ABA or a salt thereof by using this microorganism. A transformant obtained by introducing, into a coryneform bacterium, a gene that encodes 4-amino-4-deoxychorismate lyase, a gene that encodes a para-aminobenzoate synthase component I, and a gene that encodes a para-aminobenzoate synthase component II, is capable of efficiently producing 4-ABA or a salt thereof from saccharides.

Coryneform bacterial transformant and method for producing 4-aminobenzoic acid or salt thereof using same

Improvements in or relating to organic compounds

The present disclosure provides compositions and methods for the biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid and the purification of biologically derived acetaminophen.

Biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid

The present disclosure provides compositions and methods for the biosynthetic production of choline, ethanolamine, phosphoethanolamine, and phosphocholine.

Mark T. Daly

Papers

Biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid

Biosynthetic production of choline, ethanolamine, phosphoethanolamine, and phosphocholine