M
Markku Miettinen
Researcher at National Institutes of Health
Publications - 179
Citations - 13900
Markku Miettinen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Vimentin & Sarcoma. The author has an hindex of 60, co-authored 179 publications receiving 12719 citations. Previous affiliations of Markku Miettinen include New York University & Thomas Jefferson University Hospital.
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Gastrointestinal stromal tumors: recent advances in understanding of their biology.
Markku Miettinen,Markku Miettinen,Maarit Sarlomo-Rikala,Maarit Sarlomo-Rikala,Jerzy Lasota,Jerzy Lasota +5 more
TL;DR: The cell of origin is not fully understood, but resemblance to the interstitial cells of Cajal, expression of some smooth muscle markers, and occurrence outside of the GI-tract suggest origin from multipotential cells that can differentiate into Cjal and smooth muscle cells.
Journal Article
CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34
TL;DR: Results indicate that CD117 is a specific marker for GIST among tumors that occur in the GI tract and adjacent regions, and separates GISTs from true leiomyomas and gastric schwannomas.
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Gastrointestinal stromal tumors--value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas
TL;DR: It is shown that gastrointestinal mesenchymal tumors can be immunophenotypically divided in categories that correlate with light microscopically defined diagnostic entities, namely typical leiomyomas, schwannomas, and GIST, most cases of the latter representing tumors of primitive meschymal cells that are CD34 positive.
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GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Markku Miettinen,Peter McCue,Maarit Sarlomo-Rikala,Janusz Rys,Piotr Czapiewski,Krzysztof Wazny,Renata Langfort,Piotr Waloszczyk,Wojciech Biernat,Jerzy Lasota,Zengfeng Wang +10 more
TL;DR: GATA3 is a useful marker in the characterization of not only mammary and urothelial but also renal and germ cell tumors, mesotheliomas, and paragangliomas, which sets these tumors apart from epithelial neuroendocrine tumors.
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Solitary fibrous tumor: Histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites
Cheryl A. Hanau,Markku Miettinen +1 more
TL;DR: It is concluded that SFT is a neoplasm of fibroblasts/primitive mesenchymal cells with features of multidirectional differentiation, and the finding of a novel site for SFT, the parotid gland is reported.