M
Marshal Shlafer
Researcher at University of Michigan
Publications - 37
Citations - 2043
Marshal Shlafer is an academic researcher from University of Michigan. The author has contributed to research in topics: Ischemia & Superoxide dismutase. The author has an hindex of 22, co-authored 37 publications receiving 2019 citations. Previous affiliations of Marshal Shlafer include University of Arizona.
Papers
More filters
Journal ArticleDOI
Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart.
TL;DR: It is concluded that supplementing hypothermic cardioplegia solution with enzymes gave protection which was significantly better than that obtained with the other interventions, with values of these indicators not significantly different from those of nonischemic perfused controls.
Journal ArticleDOI
Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.
TL;DR: It is concluded that myocardial protection by SOD or CAT is model dependent and in conscious dogs subjected to 3 hr of coronary occlusion followed by reperfusion, SOD and CAT failed to alter size of infarction.
Journal Article
Possible role for cytotoxic oxygen metabolites in the pathogenesis of cardiac ischemic injury.
TL;DR: The results suggest that a component of "ischemic" cardiac damage may involve cytotoxicity from oxygen metabolites such assuperoxide anion, hydrogen peroxide, or both, and that this component of damage can be reduced by enzyme supplements such as superoxide dismutase or catalase.
Journal ArticleDOI
Involvement of hydrogen peroxide and hydroxyl radical in the ‘oxygen paradox’: Reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase
TL;DR: The data suggest that an important component of hypoxia-induced cardiac cell damage is due primarily to hydrogen peroxide, which may then form hydroxyl radical, but added superoxide dismutase alone did not significantly reduce creatine kinase loss.
Journal ArticleDOI
Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts
TL;DR: The data suggest that an important component of ischemia-induced cardiac cell damage in an asanguineous setting is hydrogen peroxide-dependent, and interventions that either inhibit production of superoxide anion or degrade hydrogen peroxy offer best protection.