Showing papers by "Márta Balaskó published in 2014"
TL;DR: Age-related decline primarily affects the hypermetabolic component of central catabolic leptin actions, while the anorexigenic component is even growing stronger in the late phase of aging.
40 citations
TL;DR: The present study aimed to clarify which components of the catabolic leptin effects are influenced most strongly by aging and which ones by nutritional state-induced alterations in body composition, and suggests an unexpected increase of responsiveness to anorexigenic leptin actions in old rats.
23 citations
02 Jul 2014
TL;DR: Alarin appears to elicit a slow hypermetabolic, hyperthermic response in rats, which would characterize a catabolic (anorexic and hyper Metabolic) mediator, and further investigations are needed to clarify the complex role of alarin in energy homeostasis.
Abstract: In the background of obesity, among other factors, regulatory alterations in energy balance affecting peptide systems may also be assumed. Regulation of energy balance does not only involve maintenance of body weight but also that of metabolic rate and core temperature. The contribution of alarin, a new member of the potentially orexigenic galanin peptide family, to the regulation of energy metabolism has been recently suggested. Our aim was to analyze the thermoregulatory effects of alarin in rats. Adult male Wistar rats received full-length alarin (alarin 1–25), its truncated form (alarin 6–25Cys) or scrambled alarin in various doses intracerebroventricularly at different ambient temperatures. Oxygen consumption, heat loss (assessed by tail skin temperature) and core temperature of rats were recorded in an indirect calorimeter system. Upon alarin injection at 25 °C, an increase in oxygen consumption and continuous tail skin vasoconstriction induced a slow rise in core temperature that reached 0.5 °C b...
14 citations