M
Martin Mašata
Researcher at Academy of Sciences of the Czech Republic
Publications - 12
Citations - 568
Martin Mašata is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Nucleolus & Ribosomal RNA. The author has an hindex of 9, co-authored 12 publications receiving 542 citations. Previous affiliations of Martin Mašata include Charles University in Prague & First Faculty of Medicine, Charles University in Prague.
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Journal ArticleDOI
The nucleolus and transcription of ribosomal genes.
TL;DR: The recent results on the regulation of rRNA synthesis in relation to the functional organization of the nucleolus are discussed, and an emphasis on the situation encountered in mammalian somatic cells is put on.
Journal ArticleDOI
Ribosomal genes in focus: new transcripts label the dense fibrillar components and form clusters indicative of "Christmas trees" in situ.
Karel Koberna,Jan Malínský,Artem Pliss,Martin Mašata,Jaromíra Vecerova,Markéta Fialová,Jan Bednar,Ivan Raška +7 more
TL;DR: Stereological analysis of the clustered transcription signal suggests that nascent “Christmas trees” of rRNA associated with individual rDNA genes, sampled on the surface of thin sections, may be contorted in space and exhibit a DNA compaction ratio on the order of 4–5.5.
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Electron microscopy of DNA replication in 3‐D: Evidence for similar‐sized replication foci throughout S‐phase
Karel Koberna,Anna Ligasová,Anna Ligasová,Jan Malínský,Jan Malínský,Artem Pliss,Alan J. Siegel,Zuzana Cvačková,Zuzana Cvačková,Helena Fidlerová,Helena Fidlerová,Martin Mašata,Martin Mašata,Markéta Fialová,Markéta Fialová,Ivan Raška,Ivan Raška,Ronald Berezney +17 more
TL;DR: The much larger RS or foci typically observed by fluorescence microscopic approaches in mid‐ and late‐S‐phase, are found to be composed of smaller discrete foci that are virtually identical in size to the RS observed in early‐S-phase.
Journal Article
The supply of exogenous deoxyribonucleotides accelerates the speed of the replication fork in early S-phase.
TL;DR: It is shown that the introduction of exogenous dNTPs accelerates the replication process at the beginning of DNA synthesis only and that the availability of 2'-deoxynucleotides seems to be a rate-limiting factor for DNA replication during early S-phase.
Journal ArticleDOI
Positioning of NORs and NOR-bearing chromosomes in relation to nucleoli.
Markéta Kalmárová,Evgeny Smirnov,Evgeny Smirnov,Martin Mašata,Martin Mašata,Karel Koberna,Karel Koberna,Anna Ligasová,Anna Ligasová,Alexey Popov,Alexey Popov,Ivan Raška,Ivan Raška +12 more
TL;DR: The model of the human ribosomal genes is used to address specific aspects of the relation between large-scale order of chromosome positioning and gene activity and it is found that in HeLa and LEP cells the large- scale positioning of the NOR-bearing chromosomes with regard to nucleoli is linked to the transcription activity of rDNA.