M
Martin Tepel
Researcher at University of Southern Denmark
Publications - 231
Citations - 9137
Martin Tepel is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Kidney disease & Renal function. The author has an hindex of 45, co-authored 222 publications receiving 8589 citations. Previous affiliations of Martin Tepel include Free University of Berlin & Ruhr University Bochum.
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Journal ArticleDOI
Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine.
TL;DR: Prophylactic oral administration of the antioxidant acetylcysteine, along with hydration, prevents the reduction in renal function induced by contrast agents in patients with chronic renal insufficiency.
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Contrast-induced nephropathy: a clinical and evidence-based approach.
TL;DR: This review focuses on 4 major concerns of CIN relevant in clinical practice: what is the evidence that CIN is a clinically relevant and a dangerous condition for the patient, is there a difference in CIN rate among different contrast media, and how is that related to the physicochemical properties of different available contrast media?
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The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial.
TL;DR: In hemodialysis patients, treatment with acetylcysteine (600 mg BID), a thiol-containing antioxidant, reduces composite cardiovascular end points.
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Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity
Li-Li Zhang,Dao Yan Liu,Li Qun Ma,Zhi Dan Luo,Ting Bing Cao,Jian Zhong,Zhen Cheng Yan,Li Juan Wang,Zhi Gang Zhao,Shan Jun Zhu,Mark Schrader,Florian Thilo,Zhi Ming Zhu,Martin Tepel +13 more
TL;DR: The oral administration of capsaicin for 120 days prevented obesity in male wild type mice but not in TRPV1 knockout mice assigned to high fat diet.
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Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension
Dachun Yang,Zhidan Luo,Shuangtao Ma,Wing Tak Wong,Liqun Ma,Jian Zhong,Hongbo He,Zhigang Zhao,Tingbing Cao,Zhencheng Yan,Daoyan Liu,William J. Arendshorst,Yu Huang,Martin Tepel,Zhiming Zhu +14 more
TL;DR: It is reported that chronic TRPV1 activation by dietary capsaicin increases the phosphorylation of protein kinase A and eNOS and thus production of nitric oxide in endothelial cells, which is calcium dependent, and may represent a promising target for therapeutic intervention of hypertension.