Showing papers by "Mary E. Wlodek published in 2005"
TL;DR: It is demonstrated that uteroplacental insufficiency alters intrauterine PTHrP, placental AT(1a) expression, and perinatal calcium in association with a reduction in fetal growth, which may provide an important model for exploring the early origins of adult diseases.
Abstract: During pregnancy, parathyroid hormone-related protein (PTHrP) is one of many growth factors that play important roles to promote fetal growth and development, including stimulation of placental cal...
96 citations
TL;DR: It is found that maternal and perinatal environmental factors do not play a major role in the development of the much larger total fluid intake (water plus saline) or saline preference (proportion of thetotal fluid intake taken as saline) of the SHR.
6 citations
TL;DR: Each of the reviews by the expert authors demonstrates how perturbations to biological systems in early development, results in adult disease.
Abstract: It is well established that various adult diseases have their origins in fetal life, this concept is commonly referred to as the ‘Barker Hypothesis’. Thus, low birth weight, thinness and short body length at birth is associated with increased rates of cardiovascular disease, non-insulin dependent diabetes and obesity in adult life. This phenomenon, now referred to as the “Developmental origins of health and disease”, reflects the influences of the maternal environment around conception and fetal life, as well as the postnatal environment. When first postulated, it was suggested that such diseases originate as a result of adaptations made by the fetus when it becomes undernourished. Insults, at critical developmental stages, program cardiovascular, metabolic or endocrine adaptations and permanently change the structure and/or function of the body. As we attempt to correlate structural and functional changes with molecular parameters of disease, the study of biological systems is becoming more imperative. The impact of programming on reproduction at all developmental stages has been relatively unexplored. Each of the reviews by our expert authors demonstrates how perturbations to biological systems in early development, results in adult disease. The topics encompass:
4 citations
Journal Article•
1 citations
01 Jan 2005
TL;DR: Placental growth factors including PTHrP Uteroplacental restriction in the rat impairs fetal growth in association with alterations in mice on the following topics.
Abstract: You might find this additional information useful... This article cites 40 articles, 19 of which you can access free at: http://ajpregu.physiology.org/cgi/content/full/279/1/R31#BIBL This article has been cited by 2 other HighWire hosted articles: € [Full Text]€ [PDF] Am J Physiol Regulatory Integrative Comp Physiol, December 1,€2002; 283€(6): R1289-1292. J. P. Granger physiology Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative€ [Abstract]€ [Full Text]€ [PDF] Am J Physiol Regulatory Integrative Comp Physiol, June 1,€2005; 288€(6): R1620-R1627. Moseley M. E. Wlodek, K. T. Westcott, R. O'Dowd, A. Serruto, L. Wassef, K. M. Moritz and J. M.placental growth factors including PTHrP Uteroplacental restriction in the rat impairs fetal growth in association with alterations inon the following topics: Medline items on this article's topics can be found at http://highwire.stanford.edu/lists/artbytopic.dtl Medicine .. Hypertension Physiology .. Vasodilation Physiology .. Pregnancy Physiology .. Rats Biochemistry .. Calcium Transport Updated information and services including high-resolution figures, can be found at: http://ajpregu.physiology.org/cgi/content/full/279/1/R31 and Comparative Physiology can be found at: Additional material and information about American Journal of Physiology - Regulatory, Integrativehttp://www.the-aps.org/publications/ajpregu This information is current as of September 8, 2005 . € ISSN: 0363-6119, ESSN: 1522-1490. Visit our website at http://www.the-aps.org/.
01 Jan 2005
TL;DR: This article cites 48 articles, 27 of which you can access free at: http://ajpregu.org/cgi/content/full/288/6/R1620#BIBL Updated information and services including high-resolution figures, can be found at: www.physiology.org.
Abstract: You might find this additional information useful... This article cites 48 articles, 27 of which you can access free at: http://ajpregu.physiology.org/cgi/content/full/288/6/R1620#BIBL Updated information and services including high-resolution figures, can be found at: http://ajpregu.physiology.org/cgi/content/full/288/6/R1620 and Comparative Physiology can be found at: Additional material and information about American Journal of Physiology - Regulatory, Integrativehttp://www.the-aps.org/publications/ajpregu This information is current as of September 8, 2005 . € ISSN: 0363-6119, ESSN: 1522-1490. Visit our website at http://www.the-aps.org/.