Mary Ellen K. Salyan

TL;DR: The E-selectin binding epitope in HL60 cells is carried by unbranched terminally alpha 2-->3 sialylated polylactosamines having at least 10 monosaccharide units (4 N-acetyllactosamine units) with internal multiple fucosylation at GlcNAc.

TL;DR: Isolation and chemical characterization of ganglioside structures I-XI are described in this paper, which suggest that sialosyl-Le(x) (SLex) is a ligand expressed in human neutrophils and myelogenous leukemia HL60 cells which binds to E-selectin and possibly P- selectin.

TL;DR: A series of highly polar neolacto series (poly-N-acetyllactosaminyl) gangliosides were isolated from human placenta tissue and purified by HPLC and preparative HPTLC, among the highest molecular weight glycosphingolipids whose detailed oligosaccharide structures are presently known.

TL;DR: Application of MAb TH2 on TLC immunoblotting together with chemical analysis indicates the following points of interest: (i) the existence of extended type GSLs having the same x2 terminal structure; (ii) the chemical quantities of x2, sialosyl-x2, and extended x2 found in blood cells and in various tissues including carcinomas being nearly the same.

TL;DR: A novel series of dihydro- and tetrahydrotriazolopyridazine-1,3-dione-based amino acid derivatives were identified as very potent motilin receptor agonists and compound 11A was shown to have a significantly reduced tendency to cause receptor desensitization as compared with the motilIn receptor agonist ABT-229.