Mary M. Lunzer

TL;DR: This study demonstrates a proof of concept for tissue-selective drug targeting based on G protein-coupled receptor heterodimerization and shows that the opioid agonist ligand 6'-guanidinonaltrindole (6'-GNTI) has the unique property of selectively activating only opioid receptorheterodimers but not homomers.

TL;DR: It is concluded that in control rats, active renin andactive renin glycoforms are distributed as if in diffusion equilibrium between plasma and the myocardial interstitial space, and most cardiac renin is derived from plasma renin of renal origin.

TL;DR: The Minnesota Regional Peripheral Arterial Disease Screening Program demonstrated that individuals with PAD can be efficiently identified within the community, but that current standards of medical care are low.

TL;DR: The finding that MMG22 possesses a >106 therapeutic ratio suggests that it may be an excellent candidate for treatment of chronic, intractable pain via spinal administration.

TL;DR: A series of bivalent ligands 1-5 that contain both μ agonist and CB1 antagonist pharmacophores are synthesized for use as tools to study the functional interaction between MOP andCB1 receptors in vivo.