M
Masanobu Kohsaka
Researcher at University of Tokyo
Publications - 156
Citations - 6589
Masanobu Kohsaka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Streptomyces & Alkyl. The author has an hindex of 37, co-authored 156 publications receiving 6370 citations.
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Journal ArticleDOI
FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
Toru Kino,Hiroshi Hatanaka,Susumu Miyata,Noriaki Inamura,Michihisa Nishiyama,Toshimi Yajima,Toshio Goto,Masakuni Okuhara,Masanobu Kohsaka,Hatsuo Aoki,Takenori Ochiai +10 more
TL;DR: FFK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O.
Journal ArticleDOI
FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.
Toru Kino,Hiroshi Hatanaka,Michisane Hashimoto,Michihisa Nishiyama,Toshio Goto,Masakuni Okuhara,Masanobu Kohsaka,Hatsuo Aoki,Hiroshi Imanaka +8 more
TL;DR: FFK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O.
Journal ArticleDOI
NOCARDICIN A, A NEW MONOCYCLIC β-LACTAM ANTIBIOTIC
Hatsuo Aoki,Hei-Ichi Sakai,Masanobu Kohsaka,Toshio Konomi,Junji Hosoda,Yoshiaki Kubochi,Eiko Iguchi,Hiroshi Imanaka +7 more
TL;DR: Nocardicin A is a new monocyclic β-lactam antibiotic obtained from the fermentation broth of a strain of actinomycetes that exhibits moderate in vitro antibacterial activity against a broad-spectrum of Gram-negative bacteria including Proteus and Pseudomonas.
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Studies of an immunomodulator, swainsonine. I. Enhancement of immune response by swainsonine in vitro.
Motohiro Hino,Osamu Nakayama,Yasuhisa Tsurumi,Kimiko Adachi,Toshihiro Shibata,Hiroshi Terano,Masanobu Kohsaka,Hatsuo Aoki,Hiroshi Imanaka +8 more
TL;DR: From studies using fluorescence activated cell sorting, swainsonine was shown to enhance the expression of concanavalin A receptors of spleen cells, which induced incorporation of [3H]thymidine into mouse spleenocytes.
Journal ArticleDOI
Bicyclomycin, a new antibiotic. I. Taxonomy, isolation and characterization.
TL;DR: Lavendomycin, a new basic peptide antibiotic containing novel amino acids, has been isolated from the culture broth of a streptomyces designated as StrePTomyces lavendulae subsp.