We thank the Spanish Ministerio de Ciencia e Innovacion (Grant Nos. CTQ2007-65218 and Consolider Ingenio 2010-CSD-2007-00006 and CTQ2011-24165), the Generalitat Valenciana (Grant No. PROMETEO/2009/039 and FEDER), and the University of Alicante for generous and continuous financial support.

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Diastereoselective allylation of carbonyl compounds and imines: application to the synthesis of natural products.

A general copper-catalyzed synthesis of diaryl ethers

Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.

Analytical chemistry, as a service-oriented discipline, is entering a transition period when many of our instruments will be automated and placed online The design of these chemical measuring systems of the future will follow improved development procedures Many of these new measuring systems will have advanced interactive capabilities To summarize, there are three ways of handling difficult automation projects First is the conventional method where the system is specified, designed, implemented, tested, and modified until operative This is usually a long and complex procedure A second procedure will be similar to the first but will encompass the use of such techniques as pattern recognition to help in the generation of system control and measurement specifications However, the variables to be controlled are generally well known It is the control algorithm that is difficult to optimize, Therefore, a third approach to automation will utilize the capabilities of interactive experimentation and control These systems will permit fine tuning of the control algorithms as well as rapid interrogation of data and waveforms for significant features (information) to be used together with our knowledge and intuition to reach new conclusions Analytical chemists already have at their command significant technology and expertise so that they can contribute to the design and implementation of automated chemical measuring systems A partial list of that technology includes: understanding the instrumentation to be automated; designing a new instrument; writing the detailed specifications for the chemical methods; understanding the use of modeling techniques; and writing the detailed specifications for the data-reduction techniques required for processing the instrument signals, ie, spectral analysis and digital signal-processing techniques Analytical chemists have an exceptionally bright future, but it will require change in their skills and a significant change in the definition of their role in society

https://www.ugc.ac.in/ef/Undertaking/EMERITUS-2013-14-GEN-2625-UNDR.pdf

Allylic Sulfoxides: Useful Intermediates in Organic Synthesis

Background: Cepharanthine (CEP) is a biscoclaurine alkaloid extracted from Stephania cepharantha and has been shown to have an anti-tumour effe

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Cepharanthine Induces Autophagy, Apoptosis and Cell Cycle Arrest in Breast Cancer Cells.

Acutumine and acutumidine, chlorine containing alkaloids with a novel skeleton (1): X-ray analysis of acutumine.

As an important intermediate in the synthesis of Ib, several ways of preparing the dialdehyde (IX) were investigated and a considerable increase in total yield was achieved. Synthesis of XXXI, an intermediate in the synthesis of IIb, was also examined.

Studies on Pilocereine and Related Compounds. III. Synthesis of 2, 2', 3-Trimethoxydiphenyl Ether-4', 5- and -4', 6-dicarboxaldehyde.

Structures of acutumine (XXXVIIa) and acutumidine (XXXVIIb), isolated from Menispermum dauricum DC. and Sinomenium acutum REHD. et WILS. (Menispermaceae), were investigated. On the basis of a series of degradative and spectroscopic evidences, their structures including absolute stereochemistry are assigned to the formula XXXVIIa and XXXVIIb, respectively, which are in good agreement with the result obtained from the X-ray analyses of acutumine and acetylacutumine. Apparently, these alkaloids represent a new class of alkaloids with a novel skeleton and also provide rare examples of chlorine-containing alkaloids.

Studies on the Alkaloids of Menispermaceous Plants. CCLIX. Alkaloids of Menispermum dauricum DC. (Suppl. 7). Structures of Acutumine and Acutumidine, Chlorine-Containing Alkaloids with a Novel Skeleton

Cupric oxide catalyst improved the yield in some Ullmann condensation reactions affording diaryl ether derivatives. Though it was not concluded whether cupric oxide was the ture catalytic species or not, its efficiency was proved.

Cupric oxide as an efficient catalyst in Ullmann condensation reaction.

Isoliensinine, a new phenolic biscoclaurine type alkaloid, was isolated from Formosan "Lien Tze Hsin, " loti embryo (embryo of the seed of Nelumbo nucifera GAERTN., Fam. Nymphaeaceae) and its structure was assigned to the formula II on the basis of the cleavage reaction by sodium in liq. ammonia of its O, O-diethyl ether (IV) and of the synthesis of its O, O-dimethyl ether (III).

On the Alkaloids of Nelumbo nucifera GAERTN. VIII. Studies on the Alkaloids of Loti Embryo. (1). Structure of Isoliensinine, a New Biscoclaurine Type Alkaloid

Masao Tomita

Papers

Acutumine and acutumidine, chlorine containing alkaloids with a novel skeleton (1): X-ray analysis of acutumine.

Studies on Pilocereine and Related Compounds. III. Synthesis of 2, 2', 3-Trimethoxydiphenyl Ether-4', 5- and -4', 6-dicarboxaldehyde.

Studies on the Alkaloids of Menispermaceous Plants. CCLIX. Alkaloids of Menispermum dauricum DC. (Suppl. 7). Structures of Acutumine and Acutumidine, Chlorine-Containing Alkaloids with a Novel Skeleton

Cupric oxide as an efficient catalyst in Ullmann condensation reaction.

On the Alkaloids of Nelumbo nucifera GAERTN. VIII. Studies on the Alkaloids of Loti Embryo. (1). Structure of Isoliensinine, a New Biscoclaurine Type Alkaloid