M
Masuo Hosokawa
Researcher at Hokkaido University
Publications - 129
Citations - 4753
Masuo Hosokawa is an academic researcher from Hokkaido University. The author has contributed to research in topics: Fibrosarcoma & Antigen. The author has an hindex of 38, co-authored 129 publications receiving 4612 citations.
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Journal Article
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation.
Nobuaki Akakura,Masanobu Kobayashi,Iori Horiuchi,Akiko Suzuki,Jingxin Wang,Jian Chen,Hiroto Niizeki,Kenichi Kawamura,Masuo Hosokawa,Masahiro Asaka +9 more
TL;DR: It is suggested that constitutive expression of HIF-1alpha contributes to the survival and proliferation of pancreatic cancer cells in hypoxia and glucose deprivation through the activation of anaerobic metabolism.
Journal Article
FDG Uptake and Glucose Transporter Subtype Expressions in Experimental Tumor and Inflammation Models
Takafumi Mochizuki,Eriko Tsukamoto,Yuji Kuge,Kakuko Kanegae,S. Zhao,Kenji Hikosaka,Masuo Hosokawa,Masashi Kohanawa,Nagara Tamaki +8 more
TL;DR: The results based on models showed a high FDG uptake and high GLUT-1 expression level not only in the tumor lesion but also in the inflammatory lesion.
Journal ArticleDOI
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates
Tetsufumi Koike,Naoko Kimura,Keiko Miyazaki,Tomonori Yabuta,Kensuke Kumamoto,Seiichi Takenoshita,Jian Chen,Masanobu Kobayashi,Masuo Hosokawa,Akiyoshi Taniguchi,Tetsuhito Kojima,Nobuhiro Ishida,Masao Kawakita,Harumi Yamamoto,Hiromu Takematsu,Akemi Suzuki,Yasunori Kozutsumi,Reiji Kanangi +17 more
TL;DR: The results indicate that the metabolic shifts of cancer cells partly mediated by HIFs significantly enhance their adhesion to vascular endothelial cells, through both selectin- and integrin-mediated pathways, and suggest that this enhancement further facilitates hematogenous metastasis of cancers and tumor angiogenesis.
Journal ArticleDOI
Dominant-negative hypoxia-inducible factor-1α reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
Jian Chen,Songji Zhao,Kunihiro Nakada,Yuji Kuge,Nagara Tamaki,Futoshi Okada,Jingxin Wang,Masanobu Shindo,Fumihiro Higashino,Kohji Takeda,Masahiro Asaka,Hiroyuki Katoh,Toshio Sugiyama,Masuo Hosokawa,Masanobu Kobayashi +14 more
TL;DR: It is suggested that the disruption of the HIF-1 pathway might be effective in the treatment of pancreatic cancers by rendering the pancreatic cancer cells sensitive to apoptosis and growth inhibition induced by hypoxia and glucose deprivation.
Journal ArticleDOI
Antitumor effect of implanted ethylene-vinyl alcohol copolymer matrices containing anticancer agents on Ehrlich ascites carcinoma and P388 leukemia in mice.
Shozo Miyazaki,Shigemi Takeuchi,Wei-Min Hou,Norio Hashiguchi,Chizuko Yokouchi,Masahiko Takada,Masuo Hosokawa,Yutaka Koga,Hiroshi Kobayashi +8 more
TL;DR: It appears that EVAI copolymer can be used as a membrane for controlling the release of 5-FU or adriamycin and matrices containing anticancer agent could be useful vehicles for implanted delivery systems for anticancer agents.