M
Mathilda T.M. Mommersteeg
Researcher at University of Oxford
Publications - 30
Citations - 2559
Mathilda T.M. Mommersteeg is an academic researcher from University of Oxford. The author has contributed to research in topics: Heart development & Electrical conduction system of the heart. The author has an hindex of 17, co-authored 27 publications receiving 2238 citations. Previous affiliations of Mathilda T.M. Mommersteeg include University of Amsterdam & University College London.
Papers
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Journal ArticleDOI
Pitx2c and Nkx2-5 Are Required for the Formation and Identity of the Pulmonary Myocardium
Mathilda T.M. Mommersteeg,Nigel A. Brown,Owen W.J. Prall,Corrie de Gier-de Vries,Richard P. Harvey,Antoon F.M. Moorman,Vincent M. Christoffels +6 more
TL;DR: A cellular mechanism for pulmonary myocardium formation is suggested and the key roles played by Pitx2c and Nkx2-5 in its formation and identity are highlighted.
Journal ArticleDOI
Molecular Pathway for the Localized Formation of the Sinoatrial Node
Mathilda T.M. Mommersteeg,Willem M.H. Hoogaars,Owen W.J. Prall,Corrie de Gier-de Vries,Cornelia Wiese,Danielle E.W. Clout,Virginia E. Papaioannou,Nigel A. Brown,Richard P. Harvey,Antoon F.M. Moorman,Vincent M. Christoffels +10 more
TL;DR: The molecular pathway provides a mechanism for how pacemaker activity becomes progressively relegated to the most recently added components of the venous pole of the heart and, ultimately, to the junction of the right atrium and superior caval vein.
Journal ArticleDOI
Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3
Cornelia Wiese,Thomas Grieskamp,Rannar Airik,Mathilda T.M. Mommersteeg,Ajmal Gardiwal,Corrie de Gier-de Vries,Karin Schuster-Gossler,Antoon F.M. Moorman,Andreas Kispert,Vincent M. Christoffels +9 more
TL;DR: It is found that the head and tail represent separate regulatory domains expressing distinctive gene programs, in which Tbx18 controls the formation of the SAN head from mesenchymal precursors, on which T bx3 subsequently imposes the pacemaker gene program.
Journal ArticleDOI
Tbx18 and the fate of epicardial progenitors
Vincent M. Christoffels,Thomas Grieskamp,Julia Norden,Mathilda T.M. Mommersteeg,Carsten Rudat,Andreas Kispert +5 more
TL;DR: The T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that the genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.
Journal ArticleDOI
Formation of the Venous Pole of the Heart From an Nkx2–5–Negative Precursor Population Requires Tbx18
Vincent M. Christoffels,Mathilda T.M. Mommersteeg,Mark-Oliver Trowe,Owen W.J. Prall,Corrie de Gier-de Vries,Alexandre T. Soufan,Markus Bussen,Karin Schuster-Gossler,Richard P. Harvey,Antoon F.M. Moorman,Andreas Kispert +10 more
TL;DR: This paper found that the sinus horns formed only after heart looping by differentiation of mesenchymal cells of the septum transversum region into myocardium, and they did not derive from cells previously positive for Nkx2-5.