Matthew P. Hoffman

TL;DR: Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function, as assessed with electrical recording and with accumulation of a channel-permeant fluorescent dye.

TL;DR: The extracellular matrix is a complex, dynamic and critical component of all tissues that functions as a scaffold for tissue morphogenesis, provides cues for cell proliferation and differentiation, promotes the maintenance of differentiated tissues and enhances the repair response after injury.

TL;DR: It is reported that removal of the parasympathetic ganglion in mouse explant organ culture decreased the number and morphogenesis of keratin 5–positive epithelial progenitor cells, and acetylcholine signaling, via the muscarinic M1 receptor and epidermal growth factor receptor, increased epithelial morphogenesis and proliferation of the keratin5–positive progenitors cells.

TL;DR: The salivary gland phenotypes in mice with genetic modification of F GFs and their receptors highlight the central role of FGFs during salivARY gland branching morphogenesis.

TL;DR: FGFR2b signaling involves a regulatory network of FGFR1b/FGF1/MMP2 expression that mediates budding and duct elongation during branching morphogenesis, which suggests that both FGF1 and MMPs are essential downstream mediators of epithelial morphogenesis.