Molecular basis of bacterial outer membrane permeability.

Protein phosphorylation and regulation of adaptive responses in bacteria.

Physiological and genetic responses of bacteria to osmotic stress.

Regulatory RNAs in Bacteria

Oxidative stress responses in Escherichia coli and Salmonella typhimurium.

The expression of the genes for the major outer membrane proteins OmpF and OmpC are osmoregulated. The ompC locus was found to be transcribed bidirectionally under conditions of high osmolarity and a 174-base transcript encoded upstream of ompC was found to inhibit the OmpF production and to substantially reduce the amount of the ompF mRNA. This RNA [mRNA-interfering complementary RNA (micRNA)] has a long sequence that is complementary to the 5' end region of the ompF mRNA. We propose that the micRNA inhibits the translation of the ompF mRNA by hybridizing with it. This RNA interaction may cause premature termination of the transcription of the ompF gene or destabilization of the ompF mRNA or both.

https://www.pnas.org/content/pnas/81/7/1966.full.pdf

A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA)

Gene expression of the genetic material of cellular material or an organism is regulated or inhibited by incorporating in or along with the genetic material of the cellular material or organisms DNA or other genetic material which transcribes to an RNA which is complementary to and capable of binding to the mRNA of the genetic material of said organism. Gene expression or regulation of a gene is controlled by expressing a DNA fragment or replica of said gene inserted or positioned after a promoter in the opposite direction relative to the gene so as to regulate or inhibit the expression of said gene.

Regulation of gene expression by employing translational inhibition utilizing mRNA interfering complementary RNA

Regulation of Gene Expression by a Small RNA Transcript (micRNA) in Escherichia coli K-12

https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2883%2980364-0

Mei-Yin Chou

Papers

A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA)

Regulation of gene expression by employing translational inhibition utilizing mRNA interfering complementary RNA

Regulation of Gene Expression by a Small RNA Transcript (micRNA) in Escherichia coli K-12

DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro-OmpC protein in Escherichia coli

Réglage d'expression de gène par inhibition de la traduction en utilisant de l'ANR complémentaire interferrant avec le m-ANR