Melanie Wellington

TL;DR: This work indicates that C. albicans-mediated macrophage damage is not solely due to hypha-induced physical disruption of cellular integrity and is most consistent with a model in which filamentation is necessary but not sufficient to trigger NLRP3 inflammasome-mediated pyroptosis.

TL;DR: When exposed to the antifungal drug fluconazole, Candida albicans undergoes abnormal growth, forming three-lobed “trimeras” that turn out genetically variable progeny with varying numbers of chromosomes, increasing the odds of creating a drug-resistant strain.

TL;DR: New facets of antifungal therapy are discussed with a focus on new antIFungal formulations and the synergistic effects between drugs used in combination therapy.

TL;DR: In vivo and in vitro experiments indicate that the further study of compounds related to TAM as antifungal agents is warranted, and TAM interferes with the interaction between Myo2p and calmodulin, suggesting that TAM targetsCalmodulin as part of its mechanism of action.

TL;DR: The anti-cryptococcal activity and antifungal mechanism of estrogen receptor antagonists related to the breast cancer drugs tamoxifen and toremifene are characterized and a number of pharmacological properties desirable for an anti- cryptococcal drug are shown, including synergistic fungicidal activity with fluconazole in vitro and in vivo, oral bioavailability, and activity within macrophages.