M
Melissa R. Cruz
Researcher at University of Texas Health Science Center at Houston
Publications - 20
Citations - 1005
Melissa R. Cruz is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Enterococcus faecalis & Virulence. The author has an hindex of 12, co-authored 19 publications receiving 795 citations. Previous affiliations of Melissa R. Cruz include University of Texas at Austin & Rice University.
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Ce-Duox1/BLI-3 Generated Reactive Oxygen Species Trigger Protective SKN-1 Activity via p38 MAPK Signaling during Infection in C. elegans
TL;DR: Overall, a model is presented in which ROS generation by Ce-Duox1/BLI-3 activates a protective SKN-1 response via p38 MAPK signaling, and for the first time, SKn-1 activity is shown to be protective during infection.
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Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans
TL;DR: It is shown here that E. faecalis produces a small protein that is a potent inhibitor of the ability of C. albicans to form biofilms and reduces fungal virulence in several models, raising the possibility that it might be developed as an antifungal agent.
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Enterococcus faecalis Inhibits Hyphal Morphogenesis and Virulence of Candida albicans
TL;DR: A biologically relevant interaction between two clinically important microbes that could affect treatment strategies as well as impact the understanding of interkingdom signaling and sensing in the human-associated microbiome is demonstrated.
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A riboswitch-containing sRNA controls gene expression by sequestration of a response regulator
Sruti DebRoy,Margo Gebbie,Arati Ramesh,Jonathan R. Goodson,Melissa R. Cruz,Ambro van Hoof,Wade C. Winkler,Danielle A. Garsin +7 more
TL;DR: This work introduces riboswitch-mediated control of protein sequestration as a posttranscriptional mechanism to coordinately regulate gene expression.
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Enterococcus faecalis pCF10‐encoded surface proteins PrgA, PrgB (aggregation substance) and PrgC contribute to plasmid transfer, biofilm formation and virulence
Minny Bhatty,Melissa R. Cruz,Kristi L. Frank,Jenny A. Laverde Gomez,Fernando Andrade,Danielle A. Garsin,Gary M. Dunny,Heidi B. Kaplan,Peter J. Christie +8 more
TL;DR: It is proposed that the pheromone‐responsive, conjugative plasmids of E. faecalis have retained Prg‐like surface functions over evolutionary time for attachment, colonization and robust biofilm development.