Tomoxetine, a norepinephrine uptake inhibitor, is used to treat attention-deficit/hyperactivity disorder.

Treatment of attention-deficit/hyperactivity disorder

Gaba receptor mediated modulation of neurogenesis

The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Phenylaminopropanol derivatives and methods of their use

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT2A modulator or DRI.

Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression

Modulation of neurogenesis by pde inhibition

Substituted morpholine derivatives, such as, for instance, the compound 2-[α-(2-methoxy-phenoxy)-benzyl]-morpholine are disclosed. The claimed compounds are active on the central nervous system, and may be used as antidepressant agents.

Substituted morpholine derivatives and compositions

A 2R, 3R or 2S,3S enantiomer of a 2-( alpha -phenoxybenzyl)-morpholine derivative of formula (I): wherein R is a C1-C6 alkoxy group or a trihalomethyl group; and the pharmaceutically acceptable salts thereof are useful as an anti-depressant, in treating sleep disorders or as a minor tranquilizer.

Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof

Compounds of the formula ARE DISCLOSED, SUCH AS FOR INSTANCE O-(1,4-methano-1,2,3,4tetrahydro-6-naphthyl)-N-methyl-N-(m-tolyl) -thiocarbamate; 0(1,4-ethano-1,2,3,4-tetrahydro-6-naphthyl)-N-methyl-N-(m -tolyl)thiocarbamate; 0-(5,6,7,8-tetrahydro-2-naphthyl)-N-methyl-N-(mtolyl)-thiocarbamate; and 0-(1,4-methano-1,2,3,4-tetrahydro-6naphthyl)-N-methyl-N-(m-chlorophenyl0 -thiocarbamate. The thiocarbamic acid derivatives of the present invention have antifungal activity.

Tetrahydro-2-naphthyl ester derivatives of tinonocarbanilic acids

N-heterocyclische derivate von 1,4-methano- und 1,4-aethano-1,4-dihydround 1,2,3,4-tetrahydronaphthyloxy-aliphatischen-alkoholen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel

Melloni Piero

Papers

Substituted morpholine derivatives and compositions

Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof

Tetrahydro-2-naphthyl ester derivatives of tinonocarbanilic acids

N-heterocyclische derivate von 1,4-methano- und 1,4-aethano-1,4-dihydround 1,2,3,4-tetrahydronaphthyloxy-aliphatischen-alkoholen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel

Enantiomere von phenoxyderivaten von benzylmorpholin und salze davon, verfahren zu deren herstellung und arzneimittel, welche diese enthalten