M
Mengdi Yang
Researcher at China Pharmaceutical University
Publications - 6
Citations - 112
Mengdi Yang is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Inflammasome & Gene silencing. The author has an hindex of 4, co-authored 6 publications receiving 43 citations.
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Journal ArticleDOI
Blockade of IDO-Kynurenine-AhR Axis Ameliorated Colitis-Associated Colon Cancer via Inhibiting Immune Tolerance.
TL;DR: In this article, kynurenine (Kyn), a metabolite catalyzed by indoleamine 2,3-dioxygenase (IDO), was required for IDO-mediated T cell function, and adaptive immunity indeed played a critical role in colon cancer.
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Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
Tao Li,Bin Fu,Xin Zhang,Yunjiang Zhou,Mengdi Yang,Mengran Cao,Yaxin Chen,Yingying Tan,Rong Hu +8 more
TL;DR: In this paper, the authors found that 5-HT levels, as well as the expression of tryptophan hydroxylase 1 (TPH1), the 5HT biosynthesis rate-limiting enzyme, were significantly upregulated in colorectal tumor tissues from patients with colortal cancer.
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Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2.
TL;DR: Evidence that ROCK2 acted redundantly to maintain resistance of TMZ in TMZ-resistant gliomas is provided, and as a ROCK2 phosphorylation inhibitor, fasudil significantly suppressed proliferation of TMZ- resistant glioma in vivo and vitro via enhancing the chemosensitivity of TMZ.
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HEATR1 deficiency promotes pancreatic cancer proliferation and gemcitabine resistance by up-regulating Nrf2 signaling.
Yunjiang Zhou,Keke Wang,Yang Zhou,Tao Li,Mengdi Yang,Rui Wang,Yaxin Chen,Mengran Cao,Rong Hu +8 more
TL;DR: It is suggested that HEATR1 deficiency promotes proliferation and gemcitabine resistance of pancreatic cancer through up-regulating Nrf2 signaling, indicating that HEatR1 may be a promising therapeutic target for pancreatic cancers.
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Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway.
Yunjiang Zhou,Yang Zhou,Keke Wang,Tao Li,Mengdi Yang,Rui Wang,Yaxin Chen,Mengran Cao,Rong Hu +8 more
TL;DR: Flumethasone can potentially be used as an adjuvant sensitizer to enhance the efficacy of chemotherapeutic drugs in lung cancer and is found to inhibited Nrf2 signaling in A549 and H460 cells by promoting NRF2 protein degradation.