M
Mengmeng Li
Researcher at Nanjing University of Chinese Medicine
Publications - 6
Citations - 286
Mengmeng Li is an academic researcher from Nanjing University of Chinese Medicine. The author has contributed to research in topics: Hepatic stellate cell & Hepatic fibrosis. The author has an hindex of 6, co-authored 6 publications receiving 144 citations.
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Journal ArticleDOI
Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.
Yan Jia,Feixia Wang,Qin Guo,Mengmeng Li,Ling Wang,Zili Zhang,Shuoyi Jiang,Huanhuan Jin,Anping Chen,Shanzhong Tan,Feng Zhang,Jiangjuan Shao,Shizhong Zheng +12 more
TL;DR: A potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis is suggested.
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P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation
Ling Wang,Zili Zhang,Mengmeng Li,Feixia Wang,Yan Jia,Feng Zhang,Jiangjuan Shao,Anping Chen,Shizhong Zheng +8 more
TL;DR: The findings revealed that P53‐dependent induction of ferroptosis is necessary for ART to ameliorate CCl4‐induced hepatic fibrosis and inhibit HSC activation, and determined that tumor suppressor P53 was an upstream molecule in the facilitation of ART‐induced HSC ferroPTosis.
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Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
Feixia Wang,Yan Jia,Mengmeng Li,Ling Wang,Jiangjuan Shao,Qinglong Guo,Shanzhong Tan,Hai Ding,Anping Chen,Feng Zhang,Shizhong Zheng +10 more
TL;DR: Blockade of aerobic glycolysis by oroxylin A via inhibition of LDH-A reduced HSC contraction and attenuated liver fibrosis, suggesting LDH -A as a promising target for intervention of hepatic fibrosis.
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TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1.
Jiangjuan Shao,Jiangjuan Shao,Mengmeng Li,Zijian Guo,Chun Jin,Feng Zhang,Chunyan Ou,Yaochen Xie,Shanzhong Tan,Zhenyi Wang,Shizhong Zheng,Xiaoyong Wang +11 more
TL;DR: Investigating how CTB affects mitochondrial functions and exerts its anti-tumor activity in hepatoma cells shows that CTB merits further evaluation as a chemotherapeutic agent for the treatment of Hepatocellular carcinoma.
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Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Mengmeng Li,Jiangjuan Shao,Jiangjuan Shao,Zijian Guo,Chun Jin,Ling Wang,Feixia Wang,Yan Jia,Zhenzhu Zhu,Ziji Zhang,Feng Zhang,Shizhong Zheng,Xiaoyong Wang +12 more
TL;DR: These findings established a previously unrecognized role for copper complex in aerobic glycolysis of tumour cells, revealing the interaction between mitochondrial HK2‐mediated mitophagy and Drp1‐regulated mitochondrial fission.