M
Merry C. Nishimura
Researcher at University of California, San Francisco
Publications - 15
Citations - 4548
Merry C. Nishimura is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Hypoxia (medical) & Magnetic resonance imaging. The author has an hindex of 13, co-authored 15 publications receiving 4332 citations. Previous affiliations of Merry C. Nishimura include San Francisco General Hospital.
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Journal ArticleDOI
Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
Joshua B. Bederson,Lawrence H. Pitts,Miles Tsuji,Merry C. Nishimura,Richard L. Davis,Henry M. Bartkowski +5 more
TL;DR: In this article, the authors examined the incidence and size of infarction after occlusion of different portions of the rat middle cerebral artery (MCA) in order to define the reliability and predictability of this model of brain ischemia.
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Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.
Joshua B. Bederson,Lawrence H. Pitts,Sabelle M. Germano,Merry C. Nishimura,Richard L. Davis,Henry M. Bartkowski +5 more
TL;DR: Staining with TTC is a rapid, convenient, inexpensive, and reliable method for the detection and quantification of cerebral infarction in rats 24 hr after the onset of ischemia.
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Evaluation of 2,3,5-triphenyltetrazolium chloride staining to delineate rat brain infarcts.
TL;DR: These results demonstrate that intracardiac perfusion of 2,3,5-triphenyltetrazolium chloride is an accurate, inexpensive, and efficient staining method to detect infarcted tissue 24 and 48 hours after the onset of ischemia in rats.
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The effect of hypoxia on traumatic head injury in rats: alterations in neurologic function, brain edema, and cerebral blood flow
Naoki Ishige,Lawrence H. Pitts,Isabelle Berry,Sara G. Carlson,Merry C. Nishimura,Michael E. Moseley,Philip Weinstein +6 more
TL;DR: The results show that large areas of impact-injured brain are extremely vulnerable to secondary insults that can irreparably damage neural tissue, and provide experimental evidence for the observed adverse effects of hypoxia on outcome after human head injury.
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Effect of hypoxia on traumatic brain injury in rats: Part 1. Changes in neurological function, electroencephalograms, and histopathology.
TL;DR: The findings suggest that hypoxia, which is common in head-injured patients, very likely worsens the effect of impact injury and may account for much of the diffuse neurological dysfunction in patients with severe craniocerebral trauma.