M
Michael A. Tigges
Researcher at Chiron Corporation
Publications - 7
Citations - 730
Michael A. Tigges is an academic researcher from Chiron Corporation. The author has contributed to research in topics: Herpes simplex virus & CTL*. The author has an hindex of 7, co-authored 7 publications receiving 716 citations. Previous affiliations of Michael A. Tigges include Novartis.
Papers
More filters
Journal ArticleDOI
A Recombinant Glycoprotein Vaccine for Herpes Simplex Type 2: Safety and Efficacy
Andria Langenberg,Rae Lyn Burke,Suzanne F. Adair,Rose E. Sekulovich,Michael A. Tigges,Cornelia L. Dekker,Lawrence Corey +6 more
TL;DR: The initial phase I and II clinical trials to evaluate an HSV-2 subunit vaccine that contained derivatives of gB2 and gD2 in the MF59 adjuvant emulsion and was administered to persons seronegative for HSV or seropositive only forHSV-1 antibodies were evaluated.
Journal Article
Human herpes simplex virus (HSV)-specific CD8+ CTL clones recognize HSV-2-infected fibroblasts after treatment with IFN-gamma or when virion host shutoff functions are disabled.
TL;DR: Results suggest that the combined effects of the HSV-2 vhs and ICP47 gene products are to block Ag presentation by class I MHC, but this effect can be transiently counteracted by IFN-gamma providing an early role for CD8+ CTL in the cellular immune response to HSv-2.
Journal ArticleDOI
Mechanism of interleukin-2 signaling: mediation of different outcomes by a single receptor and transduction pathway.
TL;DR: It is suggested that the pleiotrophic effects of IL-2 are determined by different translations of the signal in the nucleus, which does not involve any known second messenger system and that can be blocked by a second T cell lymphokine, interleukin 4.
Journal ArticleDOI
Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens.
Michael A. Tigges,David M. Koelle,Karin Hartog,Rose E. Sekulovich,Lawrence Corey,Rae Lyn Burke +5 more
TL;DR: The diversity of the CD8+ response from a single individual indicated that several different antigens are recognized when presented in the context of a variety of class I HLA alleles, a pattern that markedly differs from that described for another human herpesvirus, cytomegalovirus.
Journal ArticleDOI
Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes.
David M. Koelle,Michael A. Tigges,Rae Lyn Burke,Frank W. Symington,Stanley R. Riddell,Hiyam Abbo,Lawrence Corey +6 more
TL;DR: Results suggest that HSV-induced blockade of antigen presentation by cutaneous cells to CD8+ CTL may be a mechanism by which HSV limits or evades the immune response of the host.