M
Michael Ackmann
Publications - 2
Citations - 472
Michael Ackmann is an academic researcher. The author has contributed to research in topics: Microtubule & Tau protein. The author has an hindex of 2, co-authored 2 publications receiving 436 citations.
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Journal ArticleDOI
Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias†
Stefan Barghorn,Q Zheng-Fischhöfer,Michael Ackmann,Jacek Biernat,M. von Bergen,Eva Maria Mandelkow,E. Mandelkow +6 more
TL;DR: It is found that the mutations cause a moderate decrease in microtubule interactions and stabilization, and they show no gross structural changes compared with the natively unfolded conformation of the wild-type protein, but the aggregation into PHFs is strongly enhanced, particularly for the mutants DeltaK280 and P301L.
Journal ArticleDOI
Nonsaturable Binding Indicates Clustering of Tau on the Microtubule Surface in a Paired Helical Filament-like Conformation
TL;DR: It is suggested that an early conformational change in Tau leading to paired helical filament aggregation occurs right on the microtubule surface because the C-terminal domain of tubulin is polyanionic.