The mismatch negativity (MMN) in basic research of central auditory processing: a review.

In the present article, the basic research using the mismatch negativity (MMN) and analogous results obtained by using the magnetoencephalography (MEG) and other brain-imaging technologies is reviewed. This response is elicited by any discriminable change in auditory stimulation but recent studies extended the notion of the MMN even to higher-order cognitive processes such as those involving grammar and semantic meaning. Moreover, MMN data also show the presence of automatic intelligent processes such as stimulus anticipation at the level of auditory cortex. In addition, the MMN enables one to establish the brain processes underlying the initiation of attention switch to, conscious perception of, sound change in an unattended stimulus stream. 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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Invited review The mismatch negativity (MMN) in basic research of central auditory processing: A review

Shows the many advances in the field of cognitive neurosciences. From the molecular level up to that of human consciousness, the contributions cover one of the most fascinating areas of science - the relationship between the structural and physiological mechanisms of the brain/nervous system.

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The new cognitive neurosciences

New cognitive neurosciences

If the cortex is an associative memory, strongly connected cell assemblies will form when neurons in different cortical areas are frequently active at the same time. The cortical distributions of these assemblies must be a consequence of where in the cortex correlated neuronal activity occurred during learning. An assembly can be considered a functional unit exhibiting activity states such as full activation ("ignition") after appropriate sensory stimulation (possibly related to perception) and continuous reverberation of excitation within the assembly (a putative memory process). This has implications for cortical topographies and activity dynamics of cell assemblies forming during language acquisition, in particular for those representing words. Cortical topographies of assemblies should be related to aspects of the meaning of the words they represent, and physiological signs of cell assembly ignition should be followed by possible indicators of reverberation. The following postulates are discussed in detail: (1) assemblies representing phonological word forms are strongly lateralized and distributed over perisylvian cortices; (2) assemblies representing highly abstract words such as grammatical function words are also strongly lateralized and restricted to these perisylvian regions; (3) assemblies representing concrete content words include additional neurons in both hemispheres; (4) assemblies representing words referring to visual stimuli include neurons in visual cortices; and (5) assemblies representing words referring to actions include neurons in motor cortices. Two main sources of evidence are used to evaluate these proposals: (a) imaging studies focusing on localizing word processing in the brain, based on stimulus-triggered event-related potentials (ERPs), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI), and (b) studies of the temporal dynamics of fast activity changes in the brain, as revealed by high-frequency responses recorded in the electroencephalogram (EEG) and magnetoencephalogram (MEG). These data provide evidence for processing differences between words and matched meaningless pseudowords, and between word classes, such as concrete content and abstract function words, and words evoking visual or motor associations. There is evidence for early word class-specific spreading of neuronal activity and for equally specific high-frequency responses occurring later. These results support a neurobiological model of language in the Hebbian tradition. Competing large-scale neuronal theories of language are discussed in light of the data summarized. Neurobiological perspectives on the problem of serial order of words in syntactic strings are considered in closing.

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Words in the brain's language.

Event-related brain potentials (ERPs) were recorded while 14 males and 14 females read sentences containing a reflexive pronoun that referred to a definitionally or stereotypically male or female antecedent noun. Pronouns that disagreed with the gender definition or gender stereotype of the antecedent elicited a large-amplitude positive wave. Violations of gender definitions elicited a larger positive wave than did violations of gender stereotypes. Furthermore, the positive wave elicited by stereotype violations persisted even when subjects judged these sentences to be acceptable. Finally, female subjects exhibited larger positivities than did male subjects, regardless of whether the gender mismatch involved a definitional or stereotypical antecedent. These results are taken to indicate that ERPs are sensitive to violations of gender-based occupational stereotypes and that the ERP response to stereotype violations is similar to the P600 effect elicited by a variety of syntactic anomalies.

/pdf/brain-potentials-reflect-violations-of-gender-stereotypes-268knbd5z6.pdf

Brain potentials reflect violations of gender stereotypes

Event-related brain potentials (ERPs) were recorded from 13 scalp electrodes while subjects read sentences, some of which contained either a verb that disagreed in number with the subject noun (syntactic anomaly) or a word in uppercase letters (physical anomaly). Uppercase words elicited the P300 complex of positivities, whereas agreement violations elicited a late positive shift with an onset around 500 msec and a duration of several hundred msec. These effects differed in their morphology, temporal course, amplitude, and scalp distribution. Furthermore, manipulations of the probability-of-occurrence and task relevance of the anomalies had robust effects on the response to uppercase words, but not on the response to agreement violations. Finally, these anomalies had additive effects when agreement-violating uppercase (doubly anomalous) words were presented. These results are taken to be an initial indication that the positive shift elicited by agreement violations is distinct from the P300 response to unexpected, task-relevant anomalies that do not involve the violation of a grammatical rule.

On the language specificity of the brain response to syntactic anomalies: Is the syntactic positive shift a member of the p300 family?

https://faculty.washington.edu/losterho/bio_psych_1997.pdf

Brain potentials elicited by words: word length and frequency predict the latency of an early negativity

https://www.cell.com/trends/cognitive-sciences/pdf/S1364-6613(97)01073-5.pdf

Event-related brain potentials and human language

Older adults have difficulty when executive control must be brought on line to coordinate ongoing behavior. To assess age-related alterations in executive processing, task-switching performance and event-related potential (ERP) activity were compared in young and older adults on switch, post-switch, pre-switch, and no-switch trials, ordered in demand for executive processes from greatest to least. In stimulus-locked averages for young adults, only switch trials elicited fronto-central P3 components, indicative of task-set attentional reallocation, whereas in older adults, three of the four trial types evinced frontal potentials. In response-locked averages, the amplitude of a medial frontal negativity (MFN), a component reflecting conflict monitoring and detection, increased as a function of executive demands in the ERPs of the young but not those of the older adults. These data suggest altered executive processing in older adults resulting in persistent recruitment of prefrontal processes for conditions that do not require them in the young.

Michael Bersick

Papers

Brain potentials reflect violations of gender stereotypes

On the language specificity of the brain response to syntactic anomalies: Is the syntactic positive shift a member of the p300 family?

Brain potentials elicited by words: word length and frequency predict the latency of an early negativity

Event-related brain potentials and human language

Age-Related Changes in Executive Function: An Event-Related Potential (ERP) Investigation of Task-Switching