Showing papers by "Michael D. Smith published in 1990"

Boosting beyond static scheduling in a superscalar processor

Abstract: This paper describes a superscalar processor that combines the best qualities of static and dynamic instruction scheduling to increase the performance of non-numerical applications. The architecture performs all instruction scheduling statically to take advantage of the compiler's ability to efficiently schedule operations across many basic blocks. Since the conditional branches in non-numerical code are highly data dependent, the architecture introduces the concept of boosted instructions, instructions that are committed conditionally upon the result of later branch instructions. Boosting effectively removes the dependencies caused by branches and makes the scheduling of side-effect instructions as simple as those that are side-effect free. For efficiency, boosting is supported in the hardware by shadow structures that temporarily hold the side effects of boosted instructions until the conditional branches that the boosted instructions depend upon are executed. When the branch condition is determined, the buffered side effects are either committed or squashed. The limited static scheduler in our evaluation system shows that a 1.6-times speedup over scalar code is achievable by boosting instructions above only a single conditional branch. This performance is similar to the performance of a pure dynamic scheduler.

Tγδ Cells and their Subsets in Blood and Synovial Tissue from Rheumatoid Arthritis Patients

Abstract: We have examined the frequencies of T gamma delta cells in blood, synovial fluids, and synovial membranes of patients with rheumatoid arthritis (RA) and in blood from age-matched controls. Immunocytochemical and immunohistochemical techniques were used with monoclonal antibodies BB3 and A13 to define a major and minor blood subset of T gamma delta cells respectively. Together, these antibodies identify the majority (if not all) of the peripheral blood T gamma delta cells. Significantly lower levels of T gamma delta cells were found in the blood of RA patients compared with controls, whilst higher but not significant numbers were found in the synovial fluids of paired samples. Scattered T gamma delta cells were found only in some synovial membranes with a distribution similar to the T alpha beta cells. Analysis of the two different T gamma delta-cell subsets indicated a ratio of BB3 to A13 of about 5:1 in control and RA blood. However, this ratio was less than 1:1 in the RA synovial fluids and membranes. The migratory nature of the A13+ cells could account for their predominance in these sites. The possible pathological significance of these cells in the rheumatoid synovial fluid and synovial membranes is discussed.

World Politics: An Introduction to International Relations

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Tγδ Cell Subsets in Cord and Adult Blood

Abstract: A minor population of T cells expresses a heterodimeric antigen receptor composed of gamma and delta chains (TcR-1). In blood from adults, two subsets of T gamma delta cells can be identified by the monoclonal antibodies (MoAb) BB3 and A13. Little is known about the distribution and markers of these subsets early in life. We have therefore examined both the frequencies of these cells in cord blood and their expression of the cytotoxicity-associated marker serine esterase (SE), using immunocytochemical techniques. Our data show lower percentages of TcR-1+ cells in the blood of newborns compared with that in adults. However, the ratio of the A13+/BB3+ cells was significantly higher in cord than in adult blood. Whereas virtually all the adult TcR-1+ cells in blood were SE-positive, only a small proportion of the cord blood cells carried this enzyme. This was restricted to the BB3+ T gamma delta-cell subset in the cord. Our data suggest different characteristics of the TcR-1+ cells in blood from newborns compared with adult blood, and study of the functions of the different subsets, e.g. cytotoxicity, will be important in understanding their particular role in immunity.