M
Michael Fritsche
Researcher at University of Freiburg
Publications - 4
Citations - 1075
Michael Fritsche is an academic researcher from University of Freiburg. The author has contributed to research in topics: DNA damage & Apoptosis. The author has an hindex of 4, co-authored 4 publications receiving 1069 citations.
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Journal Article
Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.
TL;DR: The results obtained are in accordance with the view that the DNA damage-induced p53 accumulation may either inhibit cell growth, allowing DNA repair processes, or, in the case of severe damage, initiate apoptosis.
Journal Article
Flavonoids activate wild-type p53
TL;DR: Data suggest that both aspects of flavonoid effects, i.e. inhibition of tumour growth through cell cycle arrest and induction of apoptosis, are functionally related to p53.
Journal Article
Enhanced p53 activity and accumulation in response to DNA damage upon DNA transfection.
TL;DR: The data suggest, that the cellular p53 response to DNA damage is sensitized by uptake of exogenous DNA.
Journal ArticleDOI
Nuclear accumulation of p53 in response to treatment with DNA-damaging agents.
Ralf D. Hess,Bettina Plaumann,Annegret Schulze Lutum,C. Haessler,Barbara Heinz,Michael Fritsche,Gerhard Brandner +6 more
TL;DR: These findings demonstrate that either the immunofluorescence techniques (indirect immun ofluorescence staining or flow cytometric analysis) or ELISA or immunoblot assays are useful methods in detecting p53 accumulation.